摘要
Abstract
Objective To investigate the clinical effect of radiotherapy combined with temozolomide in patients with high grade glioma and its influence on the incidence of toxic side effects.Methods From June 2015 to February 2018, 68 patients with high grade glioma in our hospital were selected as study objects and were randomly divided into control group and observation group with 34 cases each.The two groups were treated by operation, the control group was treated with radiotherapy after operation, and the observation group was treated with temozolamide on the basis of the control group. After 3 months of treatment, the effect of the two groups was evaluated. The inflammatory reaction and the incidence of side effects were compared between the two groups.Results The levels of HGF, TNF-a and IL-17 in the observation group were lower than those in the control group 3months after treatment (P ＜0.05) .There was no significant difference in gastrointestinal reaction, bone marrow suppression, liver function damage, radiation brain necrosis and scalp ulcer between the two groups (P＞0.05) .Conclusion Radiotherapy combined with temozolidomide in high grade glioma patients can reduce inflammatory reaction, but does not increase the incidence of side effects.关键词
放疗/替莫唑胺/高级别脑胶质瘤/炎症反应/毒副反应Key words
Radiotherapy/Temozolamide/High-grade glioma/Inflammatory reaction/Toxicity分类
医药卫生
