医学信息2019，Vol.32Issue(4)：1-4,4.DOI:10.3969/j.issn.1006-1959.2019.04.001
绝经后妇女中骨质疏松患者血清钙磷、骨代谢指标与BMD的关系
Relationship between Serum Calcium, Phosphorus and Bone Metabolism Markers and BMD in Postmenopausal Women with Osteoporosis
摘要
Abstract
Objective To investigate the correlation between serum calcium, phosphorus and bone metabolism markers and bone mineral density in postmenopausal women with osteoporosis. Methods A total of 86 postmenopausal women in our hospital were examined for bone mineral density by dual-energy X-ray absorptiometry. According to bone mineral density, 63 patients were divided into osteoporosis group and 23 patients in normal group.Serum Ca, P, β-collagen degradation products (β-CrossLaps) , N-terminal osteocalcin (N-MID) and type I collagen N-terminal propeptide (PINP) were measured and compared. According to the age, the patients were divided into 4 groups: ≤59 years old, 3 cases were set to group A, 60 to 69 years old, 10 cases were set to group B, 70 to 79 years old, 36 cases were set to group C, and ≥80 years old, 37 cases were set to group D. The correlation between bone metabolic markers and bone mineral density was analyzed. Results ①The age of osteoporosis group was (78.21±7.57) years old, higher than that of normal group (74±7.15) years old, bone mineral density was lower than normal group (P<0.01); ②Osteoporosis group β-CrossLaps, N-MID and PINP were higher than the normal group, but the difference was not statistically significant (P>0.05). There was no significant difference in calcium and phosphorus levels (P>0.05). ③β-CrossLaps was negatively correlated with BMD in group A and C. (r=-0.492, -0.035, P<0.05) , there was a positive correlation between group B and group D (r=0.318, 0.058, P<0.05); N-MID was negatively correlated with BMD in each group (r=-0.972, -0.382, -0.001, -0.153, P<0.05); PINP was positively correlated with BMD in group C (r=0.052, P<0.05) , and negatively correlated with BMD in group A, B, and D (r=-0.991, -0.515, -0.187, P<0.05); serum calcium was positively correlated with BMD in each group (r=0.362, 0.307, 0.105, 0.137, P<0.05); P in group A, group C, group D was negatively correlated with BMD (r=-0.530, -0.047, -0.029, P<0.05) , while there was a positive correlation between group B and BMD (r=0.020, P<0.05). Conclusion β-CrossLaps, N-MID, PINP and BMD are closely related and should be used in the diagnosis and treatment of osteoporosis and disease monitoring.关键词
骨质疏松症/骨代谢指标/骨密度Key words
Osteoporosis/Bone turnover markers/Bone mineral density分类
医药卫生引用本文复制引用
汪钦生,邵敏,姜涛..绝经后妇女中骨质疏松患者血清钙磷、骨代谢指标与BMD的关系[J].医学信息,2019,32(4):1-4,4.基金项目
国家自然科学基金面上项目(编号:81373654) （编号:81373654）
广东省自然科学基金项目(编号:2015A030313351) （编号:2015A030313351）
广东省科技计划项目(编号:2014A020221052) （编号:2014A020221052）
广东省中医药局项目(编号:20164010) （编号:20164010）
