摘要
Abstract
Objective To investigate the value of preoperative lymphocyte and monocyte ratio and fibrinogen in the diagnosis and preoperative evaluation of patients with differentiated adenocarcinoma in colorectal. Methods 100 patients with colorectal differentiated adenocarcinoma who underwent surgery in the Third Affiliated Hospital of Anhui Medical University from January 2010 to July 2013 were enrolled in the observation group, and 50 healthy subjects in the same period were selected as the control group. The LMR and FIB values of the two groups were compared. The best cutoff values of LMR and FIB in patients with differentiated adenocarcinoma in colorectal were determined by receiver working curve. According to the cutoff value, they were divided into high and low LMR groups, high and low FIB groups. To analyze the relationship between LMR, FIB and clinical features of colorectal cancer patients and the correlation with 5-year survival rate. Results The LMR value of the observation group (3.39±1.48) was lower than that of the control group (5.27±0.98) , and the FIB value of the observation group (3.63 ±0.60) g/L was higher than that of the control group (2.78±0.41) g/L, which was statistically significant (P <0.01). The optimal cutoff values for LMR and FIB are 3.650 and 3.495 g/L, respectively. The distant metastasis rate of the high LMR group was 4.65％, Below 21.05％ of the low LMR group, the ratio of the high LMR group was 44.19％ in the III～IV phase, which was lower than the 64.91％ in the low LMR group, the difference was statistically significant (P<0.05). The distant metastasis rate was 22.22％ in the high FIB group, Compared with 4.35％ in the low FIB group, the ratio of III to IV in the high FIB group was66.67％, which was higher than 43.48％ in the low FIB group, and the lymph node metastasis rate in the high FIB group was 59.26％, which was higher than that in the low FIB group 34.78％, the differences were statistically significant (P<0.05). The 5-year survival rate was 76.74％ in the high LMR group, which was higher than the low LMR group 47.37％, and the 5-year survival rate was 78.26％ in the low FIB group, which was higher than that in the high FIB group 44.44％, Statistically significant (P <0.01). Conclusion Preoperative LMR and FIB have certain clinical value in the auxiliary diagnosis and preoperative evaluation of patients with differentiated adenocarcinoma in colorectal cancer.关键词
结直肠中分化腺癌/淋巴细胞与单核细胞比值/纤维蛋白原/辅助诊断/术前评估Key words
Differentiated adenocarcinoma in colorectal/Lymphocyte to monocyte ratio/Fibrinogen/Assisted diagnosis/Preoperative evaluation分类
医药卫生
