摘要
Abstract
Objective To investigate the relationship between serum uric acid and asymptomatic cerebral infarction in young and middle-aged.Methods A total of 300 young and middle-aged patients in our hospital were enrolled. According to the clinical neurological deficit symptoms and brain MRI or CT results, they were divided into asymptomatic cerebral infarction group, symptomatic cerebral infarction group and control group, with 100 cases in each group. Serum uric acid, blood lipids, and blood glucose levels were measured in three groups of patients. Patients with hyperuricemia and cerebral infarction were divided into oral benzbromarone-controlled blood uric acid group (control group) and non-controlled uric acid group (non-control group). The control group received oral drug benzobromone tablets, the non-control group did not receive drug treatment, and the two groups were followed up every 3 months. Logistic multivariate regression analysis was performed on high uric acid level and middle-aged and young cerebral infarction. Results The asymptomatic cerebral infarction group, the symptomatic cerebral infarction group and the control group had41 cases, 57 cases and 18 cases of high uric acid, respectively, the difference was statistically significant (P <0.05). In the asymptomatic cerebral infarction group, 41 patients had elevated uric acid, and 17 patients had symptomatic cerebral infarction. 59 patients had normal uric acid and 7 patients had symptomatic cerebral infarction, the difference was statistically significant (P<0.05).In 98 patients with hyperuricemia cerebral infarction, there were 7 cases of symptomatic cerebral infarction or recurrence in control group (50 cases) and 17 cases of symptomatic cerebral infarction or recurrence in non-control group (48 cases) , the difference was statistically significant (P<0.05). The level of high uric acid was correlated with the occurrence and progression of cerebral infarction in young and middle-aged patients (OR=1.31, 95％CI=1.003～1.918, P<0.01). Conclusion The level of high uric acid is positively correlated with cerebral infarction in young and middle-aged patients. Controlling high uric acid can effectively prevent and reduce the progression of asymptomatic cerebral infarction in young and middle-aged patients.关键词
中青年/无症状性脑梗死/高尿酸血症/苯溴马隆Key words
Young and middle-aged/Asymptomatic cerebral infarction/Hyperuricemia/Benzbromarone分类
医药卫生
