医学信息2019，Vol.32Issue(4)：138-139,2.DOI:10.3969/j.issn.1006-1959.2019.04.044
乌司他丁联合血必净对烧伤后脓毒症患者凝血功能及全身炎性反应的影响研究
Effect of Ulinastatin Combined with Xuebijing on Coagulation Function and Systemic Inflammatory Response in Patients with Sepsis after Burn
张恺悦 1陈幼琼1
作者信息
- 1. 贵州省人民医院烧伤整形外科,贵州 贵阳 550002
- 折叠
摘要
Abstract
Objective To study the effects of combination therapy with ulinastatin and Xuebijing on coagulation function and systemic inflammatory response in post-burn sepsis. Methods The clinical data of 146 patients with post-burn sepsis diagnosed in our hospital from June 2016 to June 2018 were retrospectively analyzed and randomly divided into control group and observation group, 73 cases each. The control group was treated with conventional comprehensive treatment. The observation group was treated with ulinastatin combined with Xuebijing on the basis of the control group. The coagulation function and systemic inflammatory response of the two groups were observed before and after treatment. Results After treatment, prothrombin time (PT) , fibrinogen (FIB) , fibrinogen degradation product (FDP) , partial thromboplastin time (APTT) , and thrombin time (TT) were observed in the observation group superior to the control group, the difference was statistically significant (P<0.05); observation group TNF-α, The levels of IL-6, IL-10 and CRP were better than those of the control group, the difference was statistically significant (P<0.05). Conclusion Combined treatment with ulinastatin and Xuebijing can improve blood coagulation, reduce inflammatory reaction and promote rehabilitation of patients with post-burn sepsis.关键词
乌司他丁/血必净/脓毒症/凝血功能Key words
Ulinastatin/Xuebijing/Sepsis/Coagulation分类
医药卫生引用本文复制引用
张恺悦,陈幼琼..乌司他丁联合血必净对烧伤后脓毒症患者凝血功能及全身炎性反应的影响研究[J].医学信息,2019,32(4):138-139,2.
