摘要
Abstract
Objective To observe the clinical efficacy of metformin monotherapy and different combination regimens in the treatment of type 2 diabetes. Methods The clinical data of 108 patients with type 2 diabetes who were treated in our hospital from January 2017 to June 2018 were retrospectively analyzed. According to the treatment plan, they were divided into groups A, B and C, 36 cases in each group. Group A was treated with metformin monotherapy. Group B was treated with metformin combined with glipizide sustained-release tablets. Group C was treated with metformin combined with saxagliptin. The fasting blood glucose (FPG) , postprandial 2 h blood glucose (2 hPG) , glycosylated hemoglobin (HbA1c) levels were recorded. The incidence of hypoglycemia was compared and the total effective rate of the three groups was compared. Results The total effective rate was 97.22％ in group A, 94.44％ in group B and 94.44％ in group C, the difference was not statistically significant (P>0.05). After treatment, the levels of FPG, 2 hPG and HbA1c decreased, there was significant difference between the two groups (P<0.05). The FPG, 2 hPG level and B group FPG level in group C were better than those in group A, the difference was statistically significant (P<0.05).There was no significant difference in the indexes between groups B and C (P>0.05). There was no hypoglycemia in group A and group C, and 4 cases of hypoglycemia occurred in group B, the incidence rate was 11.11％. Group C liver and kidney function There were 3 abnormalities, the incidence rate was 8.33％. Conclusion Metformin monotherapy and different combination regimens can achieve better curative effect on type 2 diabetes, but the combination can play a synergistic role to better control blood sugar levels. The clinical choice can be based on the patient's specific conditions.关键词
二甲双胍/联合用药/2型糖尿病Key words
Metformin/Combination therapy/Type 2 diabetes分类
医药卫生
