摘要
Abstract
Objective To observe the clinical value of combined detection of PCT, IL-6 and CRP levels in predicting chorioamnionitis and early onset sepsis in patients with premature rupture of fetal membranes. Methods 70 patients with premature rupture of fetal membranes (PPROM) who were treated in our hospital from January 2017 to June 2018 were enrolled in the observation group. 70 pregnant women who were normal in the gestational week of our hospital were selected as control group,according to pathological examination, the observation group was divided into chorioamnionitis group and non-chorioamnionitis group.At the same time, according to the neonatal infection, it was divided into sepsis group and non-infected group. The expressions of PCT, IL-6 and CRP in peripheral blood and cord blood were compared between the observation group and the control group. The pathological examination of the placenta membrane of the pregnant women in the observation group and the neonatal infection were followed. Results The levels of PCT, IL-6 and CRP in the peripheral blood of the pregnant women in the observation group were higher than those in the control group, the difference was statistically significant (P <0.05).The level of PCT,IL-6,CRP in non-chorioamnionitis group was significantly lower than that in chorioamnionitis group,the difference was statistically significant (P <0.05); the sensitivity of combined detection of PCT, IL -6 and CRP in the diagnosis of chorioamnionitis was 68.75％, specificity was 93.75％, positive predictive value was 97.05％; cord blood PCT, IL -6. The level of CRP was significantly increased in neonates in the septic group. Compared with the neonates in the non -infected group and the control group, the difference was statistically significant (P <0.05). Conclusion The peripheral blood of PPROM is higher in PCT, IL -6 and CRP. The combined detection of three indicators has high predictive value for chorioamnionitis. The detection of cord blood PCT, IL-6 and CRP levels is helpful for early diagnosis of early onset sepsis in neonates.关键词
PCT/IL-6/CRP/胎膜早破/绒毛膜羊膜炎/新生儿早发性败血症Key words
PCT/IL-6/CRP/Premature rupture of fetal membranes/Chorioamnionitis/Neonatal early sepsis分类
医药卫生
