应用化学2019，Vol.36Issue(1)：10-15,6.DOI:10.11944/j.issn.1000-0518.2019.01.180092
芳甲酸氰基芳甲酯的合成
Synthesis of Aryl Formic Acid Cyano Aryl Methyl Esters
摘要
Abstract
Aryl formic acid cyano aryl methyl esters are important organic synthesis intermediate presently obtained from highly toxic cyanide. In this study, K4[Fe (CN) 6]as a green cyanide source combined with acyl chlorine was used to synthesize this type of cyanohydrin ester in a one pot two-steps reaction. Optimized reaction condition was obtained by changing the temperature in second step, the reaction time, the dosages of sodium borohydride and the catalysts, Ten aryl formic acid cyano aryl methyl esters (2a ～ 2j) were synthesized in 61. 7％ ～ 80. 3％ yield. Their structures were confirmed by Fourier transform infrared spectrometer (FTIR) and nuclear magnetic resonance spectrometer (NMR) . A possible reaction mechanism was also proposed. This method avoids the use of highly toxic cyanide, and benefits from high yield, simple operation, and convenient post-processing.关键词
芳甲酸氰基芳甲酯/K4[Fe (CN) 6]/氰化反应/绿色合成Key words
aryl formic acid cyano aryl methyl esters/potassium hexacyanoferrate (Ⅱ)/acyanide reaction/green synthesis分类
化学化工引用本文复制引用
周立王,赵宙兴..芳甲酸氰基芳甲酯的合成[J].应用化学,2019,36(1):10-15,6.基金项目
青海大学2016年专业核心课程建设项目 (2016ZYHXKC09) （2016ZYHXKC09）
