应用化学2019，Vol.36Issue(1)：16-23,8.DOI:10.11944/j.issn.1000-0518.2019.01.180048
微波-超声复合场辅助水介质砜类化合物合成
Combined Microwave and Ultrasound Irradiation Assisted Synthesis of Sulfones in Aqueous Media
摘要
Abstract
A green, efficient and simple method for the synthesis of sulfones under combined microwave and ultrasound irradiation was developed. The aromatic methyl phenyl sulfones were synthesized from arylmethyl chlorides and sodium benzenesulfonates in aqueous media under combined microwave and ultrasound irradiation. The effects of microwave power, ultrasonic power, materials molar ratio, substrate concentration and irradiation time were investigated. The optimal conditions for the synthesis of benzyl phenyl sulfone are:microwave power, 40 W; ultrasonic power, 50 W; molar ratio of benzyl chloride and sodium benzene sulfonate, 1∶ 3; reaction time, 5 min. The obtained yield is 83％ under these conditions. Compared with the reaction in oil bath, the reaction was accelerated about 42 times. Twenty three sulfones have been successfully synthesized with broad substrate generality.关键词
砜/微波/超声Key words
sulfone/microwave/ultrasound分类
化学化工引用本文复制引用
谷旭晗,彭延庆,黄兮,王佳毅,宋恭华..微波-超声复合场辅助水介质砜类化合物合成[J].应用化学,2019,36(1):16-23,8.基金项目
国家重点研发计划 (2017YFD0200504) 资助 （2017YFD0200504）
