中国病理生理杂志2019，Vol.35Issue(2)：326-331,6.DOI:10.3969/j.issn.1000-4718.2019.02.022
虫草素对MPTP诱导的帕金森病小鼠运动与认知能力的影响
Effects of cordycepin on motor and cognition in Parkinson disease mice induced by MPTP
摘要
Abstract
AIM:To investigate the effects of cordycepin on the motor and cognition in Parkinson disease mice induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP).METHODS:C57BL/6 mice were intraperitoneally injected with MPTP at a dose of 30 mg/kg daily for consecutive 8 d to establish the model of Parkinson disease.HE staining was used to observe the cell number in the substantia nigra pars compacta (SNpc) from the mice.Western blot was used to detect the protein level of tyrosine hydroxylase (TH) in substantia nigra (SN).The effects of cordycepin on the motor, emotional change and cognitive behavior of the Parkinson disease mice were examined by open-field test (OFT) , spontaneous alternating behavior (SAB) and water maze test (WMT) , respectively.RESULTS:Cordycepin significantly reduced the apoptosis of cells in SNpc and reversed the decrease in the expression of TH in SN induced by MPTP (P<0.05).Furthermore, cordycepin was able to improve the average speed in OFT (P<0.05) , and increased the total number of arm entry and the accuracy in SAB (P<0.05) , but had no obvious effect on the latency in WMT.CONCLU-SION:Cordycepin is capable of attenuating the impairments of motor and explorative ability in the early stage of Parkinson disease mice, but does not alter the cognitive dysfunction.关键词
虫草素/帕金森病/1-甲基-4-苯基-1, 2, 3, 6-四氢吡啶/黑质致密部/酪氨酸羟化酶Key words
Cordycepin/Parkinson disease/1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine/Substantia nigrapars compacta/Tyrosine hydroxylase分类
医药卫生引用本文复制引用
刘丽,罗广轩,林健琳,关燕清,刘文晓,肖鹏,李楚华..虫草素对MPTP诱导的帕金森病小鼠运动与认知能力的影响[J].中国病理生理杂志,2019,35(2):326-331,6.基金项目
广州市科技计划项目(No.201510010171) （No.201510010171）
华南师范大学研究生创新计划项目 （）
