中国肺癌杂志2019，Vol.22Issue(1)：45-51,7.DOI:10.3779/j.issn.1009-3419.2019.01.09
JAK/STAT信号通路在肺癌中的研究进展
Research Advances of JAK/STAT Signaling Pathway in Lung Cancer
杨昕 1唐哲 2张鹏 1张莉1
作者信息
- 1. 华中科技大学同济医学院附属同济医院肿瘤科 430030 武汉
- 2. 华中科技大学同济医学院附属同济医院泌尿外科 430030 武汉
- 折叠
摘要
Abstract
Janus kinase (JAK) /signal transducer and activator of transcription (STAT) signaling pathway is one of the downstream pathways of cytokine signaling transduction.It regulates cell development, differentiation, proliferation, apoptosis and so on.The pathway is not only involved in the regulation of normal physiological processes, but also significant in the development of tumors, especially in hematologic malignancies.In recent years, with the further research of JAK/STAT signaling pathway, it has been found that the pathway also plays a key role in the development of solid tumors.Here we reviewed the research advances of JAK/STAT signaling pathway in lung cancer, especially the mechanisms of development, metastasis and drug resistance, and the application of inhibitors which targeting JAK/STAT signaling pathway in the treatment of lung cancer.关键词
JAK-STAT信号通路/肺肿瘤/耐药/抑制剂Key words
JAK/STAT signaling pathway/Lung neoplasms/Drug resistance/Inhibitors引用本文复制引用
杨昕,唐哲,张鹏,张莉..JAK/STAT信号通路在肺癌中的研究进展[J].中国肺癌杂志,2019,22(1):45-51,7.
