中国感染控制杂志2019，Vol.18Issue(2)：93-98,6.DOI:10.12138/j.issn.1671-9638.20194310
磷霉素钠体外联合药敏研究
In vitro combination antimicrobial susceptibility of fosfomycin sodium
摘要
Abstract
Objective To evaluate in vitro antimicrobial effect of fosfomycin sodium single use and combination with other antimicrobial agents on clinically isolated Staphylococcus aureus (S.aureus), Klebsiella pneumoniae (K.pneumoniae) and Pseudomonas aeruginosa (P.aeruginosa) in China.Methods Combined antimicrobial susceptibility testing was performed with checkerboard method, minimal inhibitory concentrations (MICs) were detected by two-fold agar dilution method, susceptibility of S.aureus (n=113 strains), K.pneumoniae (n=108 strains), and P.aeruginosa (n=110 strains) isolated from 18 hospitals in China in recent three years was determined by single and combined antimicrobial susceptibility testing.Results MIC50 value of fosfomycin sodium single use were all≤32 mg/L against all tested strains, regardless of whether strains were resistant to other antimicrobial agents or not.The synergistic rate of fosfomycin sodium with levofloxacin, minocycline, oxacillin, and clindamycin against methicillin-resistant S.aureus (MRSA) was＞43％.Synergistic rate of fosfomycin sodium with levofloxacin and imipenem against imipenem-nonsusceptible P.aeruginosa was＞35％, synergistic rates of fosfomycin sodium with tested antimicrobial agents against imipenem-susceptible P.aeruginosa were all＞35％.Conclusion Fosfomycin sodium still has good antimicrobial activity against common clinical drug-resistant bacteria, such as MRSA, extended-spectrumβ-lactamase-producing K.pneumoniae and so on, it has synergistic effect with many other kinds of antimicrobial agents, suggesting that in the limited treatment of infection caused by drug-resistant bacteria, fosfomycin in combination with other antimicrobial agents may be a useful choice.关键词
磷霉素钠/体外/联合/药物敏感试验/最低抑菌浓度/协同作用Key words
fosfomycin sodium/in vitro/combination/antimicrobial susceptibility testing/minimal inhibitory concentration/synergy effect分类
医药卫生引用本文复制引用
李耘,薛峰,刘健,杨维维,张佳,郑波..磷霉素钠体外联合药敏研究[J].中国感染控制杂志,2019,18(2):93-98,6.基金项目
国家科技支撑计划基金资助项目(2012EP001002) （2012EP001002）
