中国感染控制杂志2019，Vol.18Issue(2)：115-119,5.DOI:10.12138/j.issn.1671-9638.20194143
内脏利什曼病死亡病例的临床分析
Clinical analysis on death cases of visceral leishmaniasis
摘要
Abstract
Objective To understand the clinical characteristics and changes in laboratory indicators of patients died of visceral leishmaniasis (VL).Methods Clinical data of 4 patients died of VL in Beijing Friendship Hospital from January 2013 to June 2018 were analyzed, differences in laboratory indicators were compared.Results Disease course of 4 cases of VL ranged from3 to 12 months, all patients had multiple organ damage, including 3 cases with hepatomegaly and splenomegaly, 2 cases with central nervous system damage.IgG antibodies of leishmania were positive in 4 patients, Leishman-Donovan body was found in bone marrow smears.Routine peripheral blood test results in 4 patients decreased significantly, albumin decreased significantly and globulin increased;level of serum sodium ion in 4 patients was lower than 135 mmol/L.Conclusion Long disease course, multiple organ damage, involvement of central nervous system, significant reducing in peripheral blood routine test results, hypoproteinemia, and hyponatremia in patients with VL all indicate poor prognosis and high mortality.关键词
内脏利什曼病/利什曼原虫/低蛋白血症/低钠血症/预后Key words
visceral leishmaniasis/leishmania/hypoproteinemia/hyponatremia/prognosis分类
医药卫生引用本文复制引用
李小丽,王非,王磊,郑晓燕,黄敏君,李晶晶,贾永根,邹洋..内脏利什曼病死亡病例的临床分析[J].中国感染控制杂志,2019,18(2):115-119,5.基金项目
国家自然科学基金(81702018) （81702018）
北京市卫生系统高层次卫生技术人才培养计划(2015-3-010) （2015-3-010）
热带病防治研究北京市重点实验室开放课题项目(2017-3-3) （2017-3-3）
首都医科大学校自然(PYZ2017010) （PYZ2017010）
