中国感染控制杂志2019，Vol.18Issue(3)：271-276,6.DOI:10.12138/j.issn.1671-9638.20194145
血小板活化及其相关免疫反应在脓毒症中的作用
The role of platelet activation and related immune response in sepsis
摘要
Abstract
Platelet activation plays an important role in the occurrence and development of sepsis. During sepsis stage, platelet activation can cause endothelial cell damage, promote the formation of neutrophil extracellular traps (NETs) and microthrombosis, aggravate coagulation dysfunction and inflammatory response disorder, and ultimately lead to multiple organ dysfunction syndrome (MODS) in septic patients. During the infection, platelets also participate in the process of congenital immune response and acquired immune response, through the interaction with immune mediators, platelets can actively defend the invasion and spread of pathogens, but also may aggravate the disease and even cause septic shock due to overactive immune response. This paper mainly introduces the role of platelet activation in the occurrence and development of sepsis, and highlights the role of platelet-mediated immune response in anti-infection of human body.关键词
血小板活化/脓毒症/炎症反应/免疫反应Key words
platelet activation/sepsis/inflammatory response/immune response分类
医药卫生引用本文复制引用
江贵军,吕菁君..血小板活化及其相关免疫反应在脓毒症中的作用[J].中国感染控制杂志,2019,18(3):271-276,6.基金项目
国家自然科学基金(No:81372020) （No:81372020）
武汉大学人民医院引导基金(No:RMYD2018Z15) （No:RMYD2018Z15）
