中国骨伤2019，Vol.32Issue(4)：377-382,6.DOI:10.3969/j.issn.1003-0034.2019.04.017
TGF-β1与腱病关系的研究进展
Progress on relationship between transforming growth factor-betal and tendinopathy
高奉 1刘玉杰 2李春宝 1周敬滨 1申学振 1胡波 2鹿鸣 1刘雨丰 1张柏青 3方业汉1
作者信息
- 1. 解放军总医院骨科,北京 100853
- 2. 国家体育总局运动医学研究所,北京 100061
- 3. 北京朝阳中西医结合急诊抢救中心,北京 100022
- 折叠
摘要
Abstract
As a common soft tissue disease,the mechanism of tendinopathy has not been clarified and is lack of effective treatment method. Change of tissue fibrosis is the one of the main pathological features. Transforming growth factor beta 1(TGF-β1), which is one of the important factor,participated in fibrosis. Inconsonant expressions of TGF-β1 could be found in tendinopathy. The studies are still controversial, but the vast majority of studies had showed that TGF-β1 was abnormal, and it is given priority to increase, which means that TGF-βl plays an important role in the process of tendinopathy. In the process of tendon injuries and repairs, the time of TGF-βl increasing is inconsistent. The time for TGF-β 1 plays a significant role has not been determined. TGF-βl has abnormal expressions in both tendinopathy and tendon repairs, which are two opposite processes. Thus,it may not be a one-way adjustment factor,but has a pleiotropic. Recent studies showed that TGF-βl was considered as binding to receptor and transferring signal into the cell. Now there are three different receptors are found. The classical pathway of TGF-βl in intracellular signal transduction is mainly through activation of Smad pathway. In the same time,there are also some non-classical pathways. TGF-βl could break balance of extracellular matrix,which may be a reason to cause tendinopathy. But the regulations of TGF-βl on the extracellular matrix are complex and diverse,further studies are required. Existing researches showed that the performance of treatments on tendinopathy is unsatisfied by blocking TGF-βl downstream pathway. Therefore,it is a good way to study the upstream mechanism of produce TGF-βl. It may be an effective method to find new targets to inhibit the development of tendinopathy better by finding the original source of TGF-β1.关键词
肌腱病/转化生长因子βl/综述文献Key words
Tendinopathy/Transforming growth factor betal/Review literature分类
医药卫生引用本文复制引用
高奉,刘玉杰,李春宝,周敬滨,申学振,胡波,鹿鸣,刘雨丰,张柏青,方业汉..TGF-β1与腱病关系的研究进展[J].中国骨伤,2019,32(4):377-382,6.
