中国口腔种植学杂志2018，Vol.23Issue(4)：155-159,179,6.
富血小板纤维蛋白(PRF)促进脱位再植牙牙周膜性愈合的动物实验研究
Effects of platelet-rich fibrin (PRF) on periodontal ligament healing in dislocation replantation
摘要
Abstract
Objective: To investigate the effect of platelet-rich fibrin (PRF) on promoting periodontal healing by replantation of canine dislocation. Methods: 10 adult mongrel dogs were selected and the upper and lower anterior teeth were pulled out at intervals. Whole blood was extracted from jugular vein to prepare PRF and PRP. The dislocated teeth were randomly divided into groups according to 30 min, 1h and 2h after dry placement in vitro. The infected teeth in each group were replanted with PRF, PRP or without any graft, and immediate replantation was used as the control group. Histological observation was used to evaluate the periodontal healing in each group. Results: The first group presented normal periodontal membrane structure. No inflammatory changes and inflammatory absorption, no inflammatory changes and inflammatory absorption occurred in groups 3 and 4, and the difference in normal periodontal membrane and surface absorption was not statistically significant (P>0.05). The periodontal membrane structure of the fourth group and the seventh group had relatively dense collagen fiber structure and strong directivity. There was no significant difference in normal periodontal membrane between the fourth group and the seventh group and the first group (P>0.05). Normal periodontal membrane of the 7 th group was higher than that of the 6 th group, while surface absorption was lower than that of the 6 th group, and the difference was statistically significant ( P <0.05). There was no significant difference in surface absorption between the 9 th group and the 10 th group (P>0.05) , but surface absorption was mostly repaired and static. Conclusion: The effect of PRF on periodontal healing was more obvious than that of the group without grafting and the group using PRP. After 2 h of dislocation, PRF/PRP was difficult to promote periodontal healing.关键词
富血小板纤维蛋白/犬/脱位再植牙/牙周膜/愈合效果Key words
platelet-rich fibrin/the dog/dislocated replantation/the periodontal ligament/the healing effect分类
医药卫生引用本文复制引用
王得利,林洋洋,西玉立,王海艳,林娜,徐颖,石屹,赵青亮..富血小板纤维蛋白(PRF)促进脱位再植牙牙周膜性愈合的动物实验研究[J].中国口腔种植学杂志,2018,23(4):155-159,179,6.基金项目
1.黑龙江省省属高等学校基本科研业务费科研项目(2017-KYYWFMY-0686) （2017-KYYWFMY-0686）
2. 牡丹江医学院教育教学改革项目(Z2016s0077) （Z2016s0077）
3. 牡丹江市科学技术计划项目(G2017d2368) （G2017d2368）
