中国临床药理学杂志2019，Vol.35Issue(7)：637-639,650,4.DOI:10.13699/j.cnki.1001-6821.2019.07.011
9例中性粒细胞缺乏患者血流感染病原菌的分布及药敏分析
Retrospective clinical analysis of 91 adult neutropenic patients with bloodstream infection
摘要
Abstract
Objective To investigate the clinical features as well as the pathogenic organisms isolated from blood samples distribution and antimicrobial susceptibility profiles in adult neutropenic patients with bloodstream infection (BSI) . Methods Electronic medical records of 91 adult neutropenic patients with BSI were reviewed from 1 June 2006 to 31 May2016 in Peking University First Hospital. Results The average age of these patients was (45. 6 ± 17. 9) years. Forty eight patients (52. 7％) were men. The patients with malignant hematologic diseases accounted for 83. 5％. The total mortality during the hospitalization period was28. 6％. The primary infective sites accounting for BSI were as follows:lungs (28. 6％) , urinary tract (11. 0％) and perianal region (7. 7％) .Gram negative bacilli was the main pathogenic organism (73. 6％) . The isolate rates of gram positive cocci and fungi were 15. 4％ and 11. 0％respectively. The most common organisms of BSI in these neutropenic patients were Escherichia coli (25. 3％) , Pseudomonas aeruginosa (18. 7％) , and Klebsiella pneumonia (15. 4％) . The rates of extended-spectrum-β-lactamases (ESBLs) producing strains of Escherichiacoli and Klebsiella pneumonia were 65. 2％ and 50. 0％. No vancomycin resistant gram positive cocci were found.Conclusion In this study, gram-negative bacteria, especially Enterobacteriaceae and Pseudomonas aeruginosa were mainly isolated strains in febrile neutropenic patients. It is important to monitor BSI bacteriological prolife and drug resistance pattern in patients with certain kinds of diseases for rational use of antibiotics and hospital infection control.关键词
中性粒细胞缺乏/血流感染/耐药性Key words
neutropenia/bloodstream infection/drug resistance分类
医药卫生引用本文复制引用
马序竹,郑波,陈旭岩,王逸群,冯莉莉..9例中性粒细胞缺乏患者血流感染病原菌的分布及药敏分析[J].中国临床药理学杂志,2019,35(7):637-639,650,4.基金项目
国家科技支撑计划资金资助项目 (2012EP001002) （2012EP001002）
