中国临床药理学杂志2019，Vol.35Issue(8)：734-736,3.DOI:10.13699/j.cnki.1001-6821.2019.08.002
重组人脑利钠肽治疗老年急性失代偿心力衰竭的临床研究
Recombinant human brain natriuretic peptide in acute decompensated heart failure
李娜丽 1陈亚军 2王怀祯 1魏锦1
作者信息
- 1. 天津市第三中心医院,天津市肝胆疾病研究所,天津市人工细胞重点实验室,卫生部人工细胞工程技术研究中心 高级病房,天津 300170
- 2. 天津市第三中心医院,天津市肝胆疾病研究所,天津市人工细胞重点实验室,卫生部人工细胞工程技术研究中心 营养科,天津 300170
- 折叠
摘要
Abstract
Objective To investigate the clinical efficacy and safety of recombinant human brain natriuretic peptide (rhBNP) in older patients with acute decompensated heart failure. Methods A total of 86 aged patients with acute decompensated heart failure who admitted to our hospital were enrolled. First, they were given recombinant human brain natriuretic peptide (rhBNP) loading doses 1. 5 μg·kg-1,3-5 min, intravenous injection, then continuous intravenous pump 0. 015 kg-1 for 3-5 days. The brain natriuretic peptide(BNP) ,left ventricular ejection fraction(LVEF) and blood urea nitrogen(BUN) ,serum creatinine(SCr) ,urine output/ intake ratio and blood pressure were compared befor and after treatment one week. Result Before and after treatment,BNP was(2387. 50 ± 1030. 99) pg·mL-1 and (783. 57 ± 476. 71) pg·mL-1; LVEF was(40. 85 ± 8. 76) ％ and(44. 35 ± 0. 94) ％; the systolic blood pressure was (135. 21 ± 15. 58) mmHg and(127. 51 ± 16. 24) mmHg; the urine output/ intake ratio was (0. 81 ± 0. 50) and (1. 26 ± 0. 24). Statistically significant differences before and after treatment were found(all P < 0. 05). Conclusion The early application of rhBNP in older patients with acute decompensated heart failure is effective and safe. It can improve cardiac function,and has no adverse effect on renal function,and increases urine output.关键词
急性失代偿性心力衰竭/重组人脑利钠肽/老年人Key words
acute decompensated heart failure/recombinant human brain natriuretic peptide/older分类
医药卫生引用本文复制引用
李娜丽,陈亚军,王怀祯,魏锦..重组人脑利钠肽治疗老年急性失代偿心力衰竭的临床研究[J].中国临床药理学杂志,2019,35(8):734-736,3.
