中国临床药理学杂志2019，Vol.35Issue(8)：737-739,3.DOI:10.13699/j.cnki.1001-6821.2019.08.003
黄芪注射液联合硫酸镁注射液治疗妊娠高血压的临床研究
Astragalus membranaceus and magnesium sulfate in gestational hypertension
阚长利 1李久民 2侯敬 1景向阳 1朱艳菊 1张金环 1郭艳巍 1陈雪荣3
作者信息
- 1. 承德医学院 附属医院 南院区 产科,河北 承德 067000
- 2. 承德县中医院 内科,河北 承德 067400
- 3. 昆明医科大学 附属延安医院 产科,昆明 650051
- 折叠
摘要
Abstract
Objective To explore the effects of magnesium sulfate in combination with astragalus membranaceus injection on the birth outcomes and expression of placenta tissue related gene of patients with gestational hypertension. Methods Seventy-six gestational hypertension patients were selected and randomly assigned to control group (n = 38) and treatment group (n = 38). The control group was given intravenous injection of 25％ magnesium sulfate (60 mL) once daily for 7 days,while the treatment group was give intravenous injection of astragalus (60 mL) on the basis of the control group once daily for 7 days. The changes of blood pressure,mean arterial pressure (MAP) and 24 h urine protein content of the two groups were compared. The placenta tissue of the two groups were collected after childbirth. Results After treatment,the total effective rates of the control group and the treatment group were86. 84％ (33/38) and 97. 37％ (37/38) ,respectively; the difference was statistically significant (P < 0. 05). There were significant differences between the control group and the treatment group in systolic blood pressure [(147. 21 ± 20. 01) mmHg vs (128. 46 ± 18. 43) mmHg],diastolic blood pressure [(90. 25 ± 15. 46) mmHg vs (73. 14 ± 14. 53) mmHg],MAP [(126. 76 ± 9. 65) mmHg vs (108. 15 ± 9. 57) mmHg] and the 24 h urine protein content [(2. 65 ±0. 87) g vs (1. 34 ±0. 79) g](P < 0. 05). Conclusion Magnesium sulfate combined with astragalus membranaceus injection can reduce the blood pressure of gestational hypertension patients,improve the pregnancy outcome; the action mechanism maybe related to the up-regulation of PLGF and MMP-9 protein expression of placenta tissue.关键词
妊娠高血压/硫酸镁/黄芪注射液/胎盘生长因子/基质金属蛋白酶-9Key words
gestational hypertension/magnesium sulfate/astragalus membranaceus injection/placenta growth factor/matrix metalloproteinase-9分类
医药卫生引用本文复制引用
阚长利,李久民,侯敬,景向阳,朱艳菊,张金环,郭艳巍,陈雪荣..黄芪注射液联合硫酸镁注射液治疗妊娠高血压的临床研究[J].中国临床药理学杂志,2019,35(8):737-739,3.
