中国临床药理学杂志2019，Vol.35Issue(8)：743-745,784,4.DOI:10.13699/j.cnki.1001-6821.2019.08.005
ADCY3和NFIL3基因多态性与中国人群克罗恩病易感性的研究
Association of polymorphisms in ADCY3 and NFIL3 with crohn's disease in Chinese individuals
摘要
Abstract
Objective To investigate the association between polymorphisms in ADCY3,C10orf55,IL18RAP,CARD9,NFIL3 and susceptibility for Crohn's disease in Chinese population. Methods A total of 192 patients with Crohn's disease and 192 healthy controls were enrolled. Polymorphisms of those genes was detected by Sequenom iPLEXTM Mass Assay platform. The relationship between gene polymorphisms and Crohn's disease susceptibility was analyzed. Results A polymorphism within ADCY3, rs6545800,was susceptibility loci for Crohn's disease. Compared with the TT genotype,CC + CT carriers were less likely to develop Crohn's disease (P = 0. 004,OR = 0. 45,95％ CI: 0. 26-0. 78) . There was a weak correlation between rs4743820 within the NFIL3 gene and the susceptibility to Crohn's disease. Compared with TT carriers,CC + CT carriers had a lower probability of experience Crohn's disease (P = 0. 056, OR = 0. 64, 95％ CI:0. 40-1. 02). In addition,we also found that CC + CT of rs4743820 carriers had a lower incidence of upper gastrointestinal lesions than TT carriers (P = 0. 017,OR = 0. 26,95％ CI: 0. 08-0. 83). Conclusion The polymorphisms in ADCY3 and NFIL3 gene are associated with susceptibility to Crohn's disease in Chinese population.关键词
基因多态性/克罗恩病/炎症性肠病/易感性Key words
genetic polymorphism/Crohn's disease/inflammatory bowel disease/susceptibility分类
医药卫生引用本文复制引用
张财斌,郑洪,晁康,朱霞,高翔,郅敏,胡品津,黄民,王雪丁..ADCY3和NFIL3基因多态性与中国人群克罗恩病易感性的研究[J].中国临床药理学杂志,2019,35(8):743-745,784,4.基金项目
国家自然科学基金资助项目(81573507,81173131) （81573507,81173131）
