中国临床药理学杂志2019，Vol.35Issue(8)：788-790,794,4.DOI:10.13699/j.cnki.1001-6821.2019.08.018
归芪白术方对顺铂所致肝毒性小鼠的保护作用
Protective effect of GuiQi Baizhu Recipe on hepatotoxicity induced by cisplatin in mice
摘要
Abstract
Objective To study the protective effect of Guiqi Baizhu Recipe(GBR) on cisplatin-induced hepatotoxicity in mice. Methods Mice were randomly divided into five groups: normal group,model group,experimental-L,M and H groups,with 10 mice in each group. The mice hepatotoxicity model were preparated by injected intraperitoneally with 2. 0 mg·mL-1 of cisplatin injection 0. 2 mL. At the same time of model,the mice in three doses experimental groups were intragastric administration GBR 4. 1,8. 2,16. 4 g·kg-1; the mice in normal and model groups were intragastric administration the same volume of distilled water,1 times a day for 28 days. The blood routine in mice were detected by automatic hematology analyzer. The alanine transaminase (ALT) ,aspartate transaminase(AST) activity in blood of the liver tissue were detected by fully automatic chemistry analyzer. Results The WBC in normal group,model group,experimental-L,- M and-H groups respectively were(12. 48 ± 1. 67) ,(4. 37 ± 0. 30) ,(6. 36 ± 0. 48) ,(7. 63 ± 0. 08) ,(7. 46 ± 1. 46) 109/L-1; the PLT in the five groups respectively were (993. 67 ± 173. 34) ,(629. 67 ± 134. 11) ,(839. 67 ± 35. 81) ,(889. 50 ± 81. 32) ,(918. 00 ± 49. 37) g·L-1; comparison between the model group with normal group,with WBC and PLT decreased, the difference was significant (all P < 0. 01); comparison experimental-L,- M and-H groups with model group,with WBC and PLT increased,the difference was significant (P < 0. 05,P < 0. 01). The ALT in the five groups respectively were (44. 33 ± 14. 36) ,(77. 33 ± 16. 77) ,(61. 00 ± 8. 19) ,(55. 33 ± 7. 51) ,(53. 33 ± 10. 26) U·L-1; the AST in the five groups respectively were (145. 33 ± 19. 35) ,(205. 67 ± 33. 26) ,(196. 67 ± 35. 12) ,(163. 00 ± 11. 27) ,(156. 33 ± 21. 55) U·L-1; comparison between the model group with normal group, the difference was significant with ALT and AST increase (all P < 0. 01); comparison experimental-H group with model group, the difference was significant with ALT and AST decrease (all P < 0. 05). Conclusion GBR can reduce the liver toxicity induced by cisplatin in mice.关键词
归芪白术方/顺铂/肝毒性/减毒作用Key words
Gui Qi Baizhu recipe/cisplatin/hepatotoxicity/detoxification分类
医药卫生引用本文复制引用
张丽昕,王磊,张苡铭,张利英,刘永琦,连小龙..归芪白术方对顺铂所致肝毒性小鼠的保护作用[J].中国临床药理学杂志,2019,35(8):788-790,794,4.基金项目
甘肃省高校重大疾病分子医学与中医药防治重点实验室开放基金资助项目(ZYX15-16-3) （ZYX15-16-3）
甘肃省科技支撑计划基金资助项目(2012 -120FKCA169) （2012 -120FKCA169）
陇原青午创新人才扶持计划基金资助项目(20L4-93 -72) （20L4-93 -72）
