中国输血杂志2019，Vol.32Issue(2)：197-199,3.DOI:10.13303/j.cjbt.issn.1004-549x.2019.02.027
抗-HCV阴性/HCV RNA阳性献血者感染2例
Follow up infection analysis of 2 anti-HCV negative/anti-HCV-RNA positive blood donors in Dehong Prefecture, Yunnan
尹以靖 1刘鱼 2郭兆富 1明帅 1排木刀 1曾文岚 1段红梅 1尹以清 1郗希 1段星3
作者信息
- 1. 德宏州中心血站,云南芒市678400
- 2. 中国医学科学院 北京协和医学院输血研究所
- 3. 德宏州疾病预防控制中心
- 折叠
摘要
Abstract
Objective Two cases of anti-HCV-negative/HCV RNA-positive blood donors were followed up to confirm the infection status of HCV virus and the changes of various indicators during early infection, which provided evidence for early diagnosis and prevention of HCV-infected donors. Methods The blood samples of initial blood donation and follow-up sampling were screened by ELISA, nucleic acid characterization, disease-borne testing, and virus typing. Results Two anti-HCV-negative/anti-HCV-RNA-positive blood donors both received two follow-up tests. The time point of positive conversion was at 50 days and 64 days, respectively. The 2 blood donors were eventually confirmed anti-HCV-positive/HCV-RNA positive. The ALT values increased at first and then decreased, whereas the viral load decreased at first and then increased. The genotypes of the two cases were 3 b and 6 n respectively. Conclusion Two blood donors were at the window period of HCV infection when they donated blood. Nucleic acid testing can effectively reduce the risk of residual blood transfusion, which is of great significance in protecting blood transfusion.关键词
无偿献血者/抗-HCV阴性/NAT阳性/检出率/窗口期Key words
unpaid blood donors/anti-HCV negative/NAT positive/the detection rate/window period分类
医药卫生引用本文复制引用
尹以靖,刘鱼,郭兆富,明帅,排木刀,曾文岚,段红梅,尹以清,郗希,段星..抗-HCV阴性/HCV RNA阳性献血者感染2例[J].中国输血杂志,2019,32(2):197-199,3.
