中国实用内科杂志2019，Vol.39Issue(4)：316-320,5.DOI:10.19538/j.nk2019040102
难治性甲状腺功能亢进的临床诊治
Clinical diagnosis and treatment of refractory hyperthyroidism
贾晓蒙 1胡晓东 1吕朝晖1
作者信息
- 1. 解放军总医院第一医学中心内分泌科,北京 100039
- 折叠
摘要
Abstract
Graves' disease (GD) is the most common cause of endogenous thyrotoxicosis, and current therapeutic options for GD include antithyroid drugs (ATD), radioactive iodine and thyroidectomy. Refractory hyperthyroidism is a rare condition in which hy?perthyroidism fails to respond to the conventional therapy of anti-thyroidal med?ications. Enlarged goiter size, high titers of thyrotropin receptor antibodies (TRAb) at diagnosis and/or at the end of the treatment, TSH suppression after drug withdrawal and compliance to the treatment have all been proposed as risk factors that predict the relapse of GD. we propose that a patient-centered professionalism should be consistently followed, and that refractory hyperthyroidism because of unsuitable therapeutic strategies should be strictly avoided in the clinical practice. For the patients with refractory hyperthyroidism, radical treatment is recommended, however, continued long-term low-dose ATD can be considered.关键词
Graves病/抗甲状腺药物/难治性甲亢/诊断治疗Key words
Graves' disease/antithyroid drug/refractory hyperthyroidism/diagnosis and treatment分类
医药卫生引用本文复制引用
贾晓蒙,胡晓东,吕朝晖..难治性甲状腺功能亢进的临床诊治[J].中国实用内科杂志,2019,39(4):316-320,5.
