中国实用内科杂志2019，Vol.39Issue(4)：358-361,4.DOI:10.19538/j.nk2019040110
代谢综合征患者42例认知功能损害特征研究
Characteristics of cognitive impairment in patients with metabolic syndrome
摘要
Abstract
Objective To explore the characteristics of cognitive impairment and the characteristics of EEG changes in patients with metabolic syndrome. Methods Totally 96 patients hospitalized between May 2017 and May 2018 were included in this study.Among them, there were 34 patients with type 2 diabetes, 20 patients with hypertension, and 42 patients with metabolic syndrome.All of them completed the physical examination, laboratory tests, assessment of cognitive function scale and the P300 test. Results There were significant differences in blood glucose, HBA1c, systolic blood pressure, BMI, waist circumference and triglyceride among the three groups (P<0.05). Compared with the patients with diabetes and hypertension, patients with metabolic syndrome had lower scores in digital memory tests, visual spatial ability, memory and total score in the memory and executive tests (P<0.05). Also the patients with metabolic syndrome had significant delayed P300 latencies than those with diabetes or hypertension (P<0.05), and decreased P300 amplitudes than diabetes group (P<0.05), but there was no significant difference compared with the hypertension group (P>0.05).Conclusion The cognitive impairment of patients with metabolic syndrome manifests itself in memory, execution, visual space, etc., and has its own damage characteristics.The event-related potential is characterized by prolonged information processing time of the prefrontal lobe and reduced processing capacity.关键词
代谢综合征/认知功能/事件相关电位/P300Key words
metabolic syndrome/cognitive function/event-related potential/P300分类
医药卫生引用本文复制引用
李强,孙芳,闫振成,祝之明..代谢综合征患者42例认知功能损害特征研究[J].中国实用内科杂志,2019,39(4):358-361,4.基金项目
国家自然科学基金(31430042,81370944,31701023) （31430042,81370944,31701023）
