中国体外循环杂志2019，Vol.17Issue(1)：18-21,4.DOI:10.13498/j.cnki.chin.j.ecc.2019.01.05
活化凝血时间和活化部分凝血活酶时间在成人体外膜肺氧合支持期间抗凝的作用探讨
The function of activated clotting time and activated partial thromboplastin time during extracorporeal membrane oxygenation in adults
尹小雪 1刘德林 1刘远 1王敏娜 1刘威 1程丽 1张奇峰 1叶钢1
作者信息
- 1. 首都医科大学附属北京潞河医院急诊监护室 101100 北京
- 折叠
摘要
Abstract
Objective Activated clotting time (ACT) has been the preferred monitoring index in extracorporeal membrane oxygenation (ECMO) patients for long. This retrospective study sought to evaluate the relationship between activated clotting time (ACT) and activated partial thromboplastin time (APTT) when they were used to monitor anticoagulation in patients undergoing extracorporeal membrane oxygenation (ECMO). Methods Patients administered with heparin during ECMO were included in this study. The primary endpoint was the relationship between paired ACT and APTT samples. Results Twenty-two patients who met the criteria for the study were included. Pearson analysis found weak correlation between ACT and APTT (r = 0.114, P = 0.003), and weak correlation between ACT and APTT was also founded in patients who benefited from venovenous ECMO (r = 0. 229, P = 0. 001). The levels of APTT (51.1±27.5 s) and ACT (196.1±35.7 s) in V-V ECMO group were different from those in V-A ECMO group (46.1±27.7 s for APTT and 205.4±33.1 s for ACT, respectively) with a statistical difference in ACT (P = 0.013). Compared with survivours, platelet count declined significantly (P ＜0.001) in nonsurvivors. Conclusion There was a weak correlation between ACT and APTT in patients supported with ECMO. The coagulation indices of different ECMO modes were different. Platelet count declined significantly during the treatment of ECMO in critical patients and was related to their prognosis.关键词
体外膜肺氧合/活化凝血时间/活化部分凝血活酶时间/抗凝/血小板Key words
Extracorporeal membrane oxygenation/Activated partial thromboplastin time/Activated clotting time/Anticoagulation/Platelet引用本文复制引用
尹小雪,刘德林,刘远,王敏娜,刘威,程丽,张奇峰,叶钢..活化凝血时间和活化部分凝血活酶时间在成人体外膜肺氧合支持期间抗凝的作用探讨[J].中国体外循环杂志,2019,17(1):18-21,4.
