中国现代手术学杂志2019，Vol.23Issue(1)：1-6,6.DOI:10.16260/j.cnki.1009-2188.2019.01.001
PD-L1和BAFF-R在胃弥漫性大B细胞淋巴瘤中的表达及其临床意义
Clinical Significance of PD-L1 and BAFF-R Expression in Gastric Diffuse Large B-cell Lymphoma and Adjacent Nontumors Tissues
摘要
Abstract
Objective To explore the clinical significance of programmed death ligand-1(PD-L1) and B-cell activating factor belonging to the TNF family-receptor (BAFF-R) expression in gastric diffuse large Bcell lymphoma (GDLBCL) and para-tumor tissues. Methods The PD-L1 and BAFF-R expression was examined in 26 matched sets of GDLBCL specimens and adjacent tissues using immunohistochemistry and quantificational reverse transcription-polymerase chain reaction (qRT-PCR). It was analyzed of the expession of PDL1 or BAFF-R with tumor stages and other pathological characteristics. And the relation of PD-L1 expression and BAFF-R in GDLBCL was explored as well. Results The PD-L1 and BAFF-R expression was significantly higher in GDLBCL than adjacent non-tumoral tissues (P＜0.01). There were significant correlations on PDL1 and BAFF-R expression with tumor stages and pathological classifications(P＜0.01), and the PD-L1 expression was correlation with BAFF-R in the GDLBCL(P＜0.01). Conclusions The up-regulated expression of PD-L1 and BAFF-R was highly correlated with the clinical stages or the pathological types of GDLBCL. Examining PD-L1 and BAFF-R expression might be valuable indications for GDLBCL inspection. Targeting PD-L1 and BAFF-R signaling pathway might be a potential immunotherapy schedule for GDLBCL.关键词
胃弥漫性大B细胞淋巴瘤/程序性死亡蛋白-1配体/B淋巴细胞活化因子受体/定量逆转录-聚合酶链反应法/肿瘤免疫治疗Key words
gastric diffuse large B-cell lymphoma/programmed death ligand-1/B-cell activating factor of the TNF family-receptor/quantificational reverse transcription-polymerase chain reaction/tumor immunotherapy分类
医药卫生引用本文复制引用
曾辉,唐松青,谢海龙,朱海珍,左朝晖,王进峰,尚松,王亮,李亚军,李俊军,邓红玉,欧阳琳达,邓日林..PD-L1和BAFF-R在胃弥漫性大B细胞淋巴瘤中的表达及其临床意义[J].中国现代手术学杂志,2019,23(1):1-6,6.基金项目
湖南省发展和改革委员会产业研发项目(2015-99) （2015-99）
湖南省科技厅重点研发计划项目(2017k2130) （2017k2130）
