中国畜牧兽医2019，Vol.46Issue(1)：185-193,9.DOI:10.16431/j.cnki.1671-7236.2019.01.021
SMAD3基因在畜牧生产中的应用研究进展
Application Research Progress of SMAD3 Gene in Livestock Production
摘要
Abstract
SMAD3gene is one of the members of the SMADs gene family, and the SMAD3 protein which encoded by SMAD3 gene, is the special intracellular signal transduction molecule of TGF-βsuper gene family.Not only SMAD3 gene participates in regulating many aspects of important physiological processes viathe superfamily of TGF-β, such as disease, immune regulation, growth and development, wound healing, development and maintenance of cartilages and bones, but also involves in regulating physiological activities in animal, for example, the proliferation, differentiation, maturation, adhesion, atresia, apoptosis of germ cells, and secretion of steroid hormone.Therefore, it''s of great significance to understand the structure and function of SMAD3 gene for the researches relating to animal growth, development and reproduction.This review sketched the structure, function, mechanism of SMAD3 gene, and analysized its research progress of the application in livestock production.It showed that a large number of researches about the application of SMAD3 gene in animal production was mainly focus on aspects of growth regulation, develop-ment, cell immunity and apoptosis, hormone secretion and reproductive performance of vertebrate (pigs, cattle, sheep, chickens, etc) .Regulations of SMAD3 gene in disease, growth and development, fat deposition and reproductive performance were still hot in domestic and abroad.However, the precise molecular regulation mechanism of this gene on disease occurrence, growth and reproductive performance remains to be further researched.关键词
SMAD3基因/转化生长因子-β (TGF-β)/作用机理/畜牧生产Key words
SMAD3 gene/transforming growth factor-β (TGF-β) /mechanism/animal production分类
农业科技引用本文复制引用
谭斌,杨胜林,杨汝才,王旭平,周美迪,周璇,杨世皓..SMAD3基因在畜牧生产中的应用研究进展[J].中国畜牧兽医,2019,46(1):185-193,9.基金项目
贵州省科技厅成果应用与产业化计划(黔科合成果[2017]4110、黔科合成果[2018]4301) （黔科合成果[2017]4110、黔科合成果[2018]4301）
贵州省科技厅科技支撑计划(黔科合NY[2015]3006-2、黔科合支撑[2017]2539) （黔科合NY[2015]3006-2、黔科合支撑[2017]2539）
贵州省普通本科高等学校科技成果转化与产业化(黔教合KY字[2017]056) （黔教合KY字[2017]056）
