中国医科大学学报2019，Vol.48Issue(1)：7-11,5.DOI:10.12007/j.issn.0258-4646.2019.01.002
TC1和β-连环蛋白在宫颈癌和癌前病变组织中表达的关系和意义
Expression of TC1 and β-catenin in Cervical Carcinoma and Precancerous Lesions and Their Significance
摘要
Abstract
Objective To investigate the expression of thyroid cancer-1 (TC1) and β-catenin in cervical carcinoma and precancerous lesions and their significance. Methods Immunohistochemical methods were used to examine the expression of TC1 and β-catenin in80 cervical squamous cell carcinoma (CSCC) tissues, 40 high-grade squamous intraepithelial lesions (HSIL), 40 low-grade squamous intraepithelial lesions (LSIL), and 30 normal cervical tissues. Results Although TC1 expression in CSCC was significantly higher than that in LSIL (P = 0.002) and normal cervical tissues (P ＜ 0.001), it was similar to that in HSIL (P = 0.576). TC1 expression was positively correlated with poor differentiation (P = 0.005) and advanced FIGO stage (P = 0.004) in CSCC. β-catenin expression in CSCC was significantly higher than that in LSIL (P ＜ 0.001) and normal cervical tissues (P ＜ 0.001), but was similar to that in HSIL (P = 0.907). The abnormal β-catenin expression was also correlated with poor differentiation (P = 0.025) and advanced FIGO stage (P = 0.001) in CSCC. TC1 expression was positively correlated with the abnormal β-catenin expression in CSCC (r = 0.294, P = 0.008) and cervical squamous intraepithelial lesions (r = 0.549, P ＜ 0.001). Conclusion TC1 and β-catenin expression in CSCC and HSIL was significantly higher than that in LSIL and normal cervical tissues. TC1 expression correlated with the abnormal β-catenin expression, and with poor differentiation and advanced FIGO stage of CSCC.关键词
甲状腺癌相关因子1/β-连环蛋白/宫颈癌/癌前病变Key words
thyroid cancer-1/β-catenin/cervical carcinoma/precancerous lesion分类
医药卫生引用本文复制引用
兰翀,聂小毳,史玉林,徐洪涛..TC1和β-连环蛋白在宫颈癌和癌前病变组织中表达的关系和意义[J].中国医科大学学报,2019,48(1):7-11,5.基金项目
国家自然科学基金 (81372497) （81372497）
辽宁省自然科学基金 (20170540833) （20170540833）
