中国医科大学学报2019，Vol.48Issue(1)：39-43,5.DOI:10.12007/j.issn.0258-4646.2019.01.008
抗氨甲酰化蛋白抗体检测在类风湿关节炎中的意义
Significance of Anti-Carbamylated Protein Antibody Measurement in the Diagnosis of Rheumatoid Arthritis
摘要
Abstract
Objective To explore the significance of serum anti-carbamylated protein (anti-CarP) antibody measurement for diagnosing rheumatoid arthritis (RA). Methods In this study, 135 patients with newly diagnosed RA (RA group) and 85 healthy subjects (healthy group) were enrolled. ELISA was performed to measure anti-CarP and anti-cyclic citrullinated peptide (anti-CCP) antibodies. The numbers of swollen and tender joints, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) level were recorded. Results Anti-CCP antibody was positive in 106 cases (78.5％) and anti-CarP antibody was positive in 67 cases (49.6％) in the RA group. The sensitivity of combined measurement of anti-CCP and anti-CarP antibodies can improve the specificity of diagnosis, up to 97.6％. Among cases of anti-CarP antibody positivity, the number of swollen and tender joints and DAS-28 score were positively correlated with anti-Car P antibody level (r = 0.61, P = 0.001;r = 0.67, P = 0.001;r = 0.62, P = 0.001, respectively) and weakly correlated with CRP level and ESR (r = 0.28, P =0.015;r = 0.35, P = 0.018, respectively), but not correlated with disease duration (r = 0.09, P = 0.43). A total of 98 cases (72.6％) had radiological changes. At different levels of joint damage severity observed on radiographs, the differences between serum anti-CarP and anti-CCP antibody levels were statistically significant (P ＜ 0.05). Conclusion Combined detection of anti-CarP and anti-CCP antibodies increases diagnostic specificity for RA. Anti-CarP antibody level is also correlated with severity of joint damage, implicating its involvement in the development and progression of RA. It may become an important marker for RA diagnosis, severity evaluation, and prognosis prediction.关键词
抗环瓜氨酸多肽抗体/抗氨甲酰化蛋白抗体/类风湿关节炎Key words
anti-circle citrullinated peptide antibody/anti-carbamylated protein antibody/rheumatoid arthritis分类
医药卫生引用本文复制引用
黄睿,张宁..抗氨甲酰化蛋白抗体检测在类风湿关节炎中的意义[J].中国医科大学学报,2019,48(1):39-43,5.基金项目
辽宁省自然科学基金 (2014021081) （2014021081）
沈阳市科技计划 (1801220) （1801220）
