中国医科大学学报2019，Vol.48Issue(1)：62-65,4.DOI:10.12007/j.issn.0258-4646.2019.01.013
乳腺癌患者口服他莫昔芬后子宫内膜异常的临床意义
Clinical Significance of Endometrial Abnormalities in Patients with Breast Cancer after Oral Administration of Tamoxifen
摘要
Abstract
Objective To analyze the clinical significance of endometrial abnormalities in patients with breast cancer after oral administration of tamoxifen, and to determine the risk factors for endometrial malignancy. Methods We collected data from 135 patients with breast cancer who underwent surgery for endometrial abnormalities after oral administration of tamoxifen at the Department of Gynecology from September 2011 to December 2017. According to the pathological results obtained, the patients were divided into groups A (benign endometrial lesion) and B (precancerous and malignant endometrial lesion). The relationships between endometrial malignancy and factors including age, menopausal status, body mass index, endometrial thickness, abnormal uterine bleeding, oral dose of tamoxifen, duration of oral medication, and complications (hypertension and diabetes) were compared between the groups. Results There were 124 patients in group A and 11 patients in group B. The difference in the incidence of abnormal uterine bleeding, which was a risk factor for endometrial malignancy, was significant different between the groups (P ＜ 0.05). Conclusion Physicians should pay close attention to abnormal uterine bleeding in patients taking tamoxifen after surgery for breast cancer. Hysteroscopy should be used to confirm the nature of lesions, and patients without symptoms should be followed up.关键词
他莫昔芬/子宫内膜病变/异常子宫出血Key words
tamoxifen/endometrial diseases/abnormal uterine bleeding分类
医药卫生引用本文复制引用
田东立,李丰鑫,邓雷,宋斐然,庞晓燕,张颐..乳腺癌患者口服他莫昔芬后子宫内膜异常的临床意义[J].中国医科大学学报,2019,48(1):62-65,4.基金项目
沈阳市科技计划 (17-231-1-54) （17-231-1-54）
