中国医科大学学报2019，Vol.48Issue(2)：101-104,4.DOI:10.12007/j.issn.0258-4646.2019.02.002
LC3在成釉细胞瘤中的表达及意义
Expression and Significance of LC3 in Ameloblastomas
摘要
Abstract
Objective To investigate the expression and significance of microtubule-associated protein 1 light chain 3 (LC3), an autophagy marker protein, in ameloblastomas. Methods Immunohistochemical methods were employed to evaluate the expression of LC3 in104 cases of ameloblastomas and 20 cases of normal oral mucosal tissues. The results were analyzed by a semiquantitative analysis method. Results The reactivity of LC3 in the epithelial cells of ameloblastomas was positive, and the positivity rate was significantly higher than that in normal oral mucosal tissues (P ＜ 0.05). There were no significant differences between the LC3 expression levels with respect to age, gender, or recurrence (P ＜ 0.05). The positivity rate in mandible ameloblastomas was significantly higher than that in maxilla and gingiva ameloblastomas (P ＜ 0.05). The reactivity for LC3 was significantly higher in solid ameloblastomas than that in the other three tissue types (P ＜ 0.05). Conclusion Autophagic activity in ameloblastomas was higher than that in normal oral mucosal tissues. This suggests that autophagy plays an important role during tumorigenesis, and contributes to the local invasion of ameloblastomas.关键词
微管相关蛋白1轻链3/成釉细胞瘤/自噬/免疫组织化学Key words
microtubule-associated protein 1 light chain 3/ameloblastoma/autophagy/immunohistochemistry分类
医药卫生引用本文复制引用
黄碧莹,刘洁,钟鸣,王珺婷,王小玢,康媛媛,孙妍,乔雪..LC3在成釉细胞瘤中的表达及意义[J].中国医科大学学报,2019,48(2):101-104,4.基金项目
国家自然科学基金 (81470758) （81470758）
辽宁省教育厅科学技术研究项目 (LK201626) （LK201626）
沈阳市中青年科技创新人才支持计划 (RC170078) （RC170078）
沈阳市科技计划 (F16-102-4-00) （F16-102-4-00）
