中国医科大学学报2019，Vol.48Issue(2)：136-139,4.DOI:10.12007/j.issn.0258-4646.2019.02.010
利多卡因持续静脉输注对腹腔镜结直肠手术患者术后疼痛的影响
Effect of Continuous Intravenous Lidocaine Administration for Pain Control in Patients Undergoing Laparoscopic Colorectal Surgery
摘要
Abstract
Objective To evaluate the effect of continuous intravenous lidocaine administration during surgery for short-term pain control in patients undergoing laparoscopic colorectal surgery, the postoperative use of opioid, and gastrointestinal function recovery. Methods Forty patients who underwent laparoscopic colorectal surgery were randomly assigned to lidocaine and control groups. Each group consisted of 20 patients. The lidocaine group received an intravenous injection of 2％ lidocaine 2 mg/kg during induction of anesthesia, followed by continuous pumping of lidocaine 1.5 mg/ (kg·h) till the end of surgery. In the control group, saline was used in place of lidocaine. The visual analogue scale (VAS), time of first defecation, amount of opioids used intraoperatively and postoperatively, postoperative nausea and vomiting, and lidocaine toxicity symptoms were recorded at 3 h, 12 h, 72 h, 5 d, 7 d, and 30 d after surgery, respectively. Results At3 h, 12 h, 72 h, 5 d, and 7 d (at rest), the VAS scores in the lidocaine group were significantly lower than those in the control group (P ＜0.05). At 72 h (on walking) and 30 d after surgery, no significant differences in VAS scores were found between the two groups. In comparison with the control group, the dosage of opioids in the lidocaine group was significantly reduced (P ＜ 0.05), the recovery of gastrointestinal function was significantly faster (P ＜ 0.05), and the symptom of nausea and vomiting were significantly reduced in the lidocaine group (P ＜ 0.05). No symptoms of lidocaine toxicity were observed in either group. Conclusion Continuous intravenous lidocaine administration during surgery is beneficial for postoperative pain control after laparoscopic colorectal surgery. It can also reduce the use of opioids and accelerate the recovery of gastrointestinal function.关键词
利多卡因/镇痛/腹腔镜/结直肠手术Key words
lidocaine/analgesia/laparoscopy/colorectal surgery分类
医药卫生引用本文复制引用
赵楠溪,曹学照,王俊..利多卡因持续静脉输注对腹腔镜结直肠手术患者术后疼痛的影响[J].中国医科大学学报,2019,48(2):136-139,4.基金项目
国家自然科学基金 (81300938) （81300938）
