中国医疗美容2019，Vol.9Issue(2)：88-91,4.DOI:10.19593/j.issn.2095-0721.2019.02.024
尼克酸治疗恶性黑素瘤的相关机制研究
Mechanism of niacin in the treatment of malignant melanoma
陈龙 1高涛 2唐海燕 2李彦希2
作者信息
- 1. 梁平区人民医院神经内科, 重庆, 405200
- 2. 重庆市中医院皮肤科, 重庆, 400011
- 折叠
摘要
Abstract
Objective To explore the prospect and mechanism of niacin in the treatment of malignant melanoma. Methods Through transwell migration experiment in vitro, the migration inhibition effect of niacin on B16-F10 melanoma cells was observed, as well as the effect of different concentrations of niacin on melanoma cells. The expression of transcription factor snail2, twist and adhesive factor E-cardherin was detected by RT-PCR. Results Through transwell in vitro migration experiments, we found that niacin significantly inhibits the migration of B16-F10 melanoma cells, and shows a concentration-dependent relationship. Niacin can significantly reduce the expression of snail2 and twist related genes in tumor cell migration (P ＜ 0.01), while E-cardherin inhibiting tumor cell migration was significantly increased. Conclusion Niacin can inhibit the migration of melanoma cells in vitro and provide theoretical basis for its treatment.关键词
尼克酸/恶性黑素瘤/迁移Key words
Niacin/Melanoma/Migration引用本文复制引用
陈龙,高涛,唐海燕,李彦希..尼克酸治疗恶性黑素瘤的相关机制研究[J].中国医疗美容,2019,9(2):88-91,4.
