摘要
Abstract
Objective To explore the clinical efficacy of carbamazepine combined with lomalazine hydrochloride capsules in the treatment of migraine. Methods According to different treatment methods, the 80 migrine patients selected from Liaoning University Hospital from March 2015 to March 2018 were divided into observation group (46 cases) and control group (34 cases). Patients in the control group were given lomethazine hydrochloride capsules orally, while the observation group was combined with carbamazepine oral administration on the basis of the control group. Both groups were treated for 90 days. The frequency of headache onset before and after treatment, duration of headache remission within 24 hours, and visual analogue scale (VAS) score before and after treatment were compared between the two groups. Adverse reactions were observed in the two groups. Results Before treatment, the frequency of headache attack and the duration of headache remission within 24 hours in the two groups were not statistically significant (P>0.05). After treatment, the frequency of headache attack was significantly reduced in the observation group, and the duration of headache relief was significantly prolonged within 24 hours. Compared the two indexes of the two groups were, the difference was statistically significant (P<0.05). Before treatment, VAS scores of the observation group and the control group were respectively (7.57±1.03) and (7.46±1.17), There was no significant difference between the groups (P>0.05). After treatment, VAS score of both groups decreased significantly. Patients in the observation group (2.07±0.86), the score was significantly lower than that of the control group (3.82±0.90). The difference between the two groups was statistically significant (P<0.05). The incidence of adverse reactions in the observation group was 13.04％, and the difference between the two groups was not statistically significant compared with 11.76％ of the control group (P>0.05). Conclusion The application of carbamazepine combined with lomerizine hydrochloride capsules for the treatment of migraine can significantly reduce the frequency of headache attack, extend the duration of headache relief for 24 hours, and reduce the pain degree of patients. There was no significant increase in adverse reactions, which means the higher safety.关键词
卡马西平/盐酸洛美利嗪/偏头痛Key words
Carbamazepine/Lomerizine hydrochloride/Migraine分类
医药卫生
