中国药物经济学2019，Vol.14Issue(1)：94-97,128,5.DOI:10.12010/j.issn.1673-5846.2019.01.025
多索茶碱联合雾化吸入药物治疗支气管哮喘急性发作期患者的临床疗效
Clinical Observation on the Effects of Doxofylline Combined with Aerosol Inhalation on Acute Attack of Bronchial Asthma
白明洁 1蔺娜1
作者信息
- 1. 大连大学附属新华医院药剂科,辽宁大连 116021
- 折叠
摘要
Abstract
Objective To analyze the therapeutic effects of aerosolized drug combined with doxofylline injection in the acute attack of bronchial asthma. Methods From January 2015 to December 2017, a tatal of 136 patients with acute bronchial asthma were treated in Xinhua Hospital affiliated to Dalian University. According to different treatment methods, they were divided into observation group and control group (n=68). The control group inhaled salbutamol and budesonide. The observation group injected intravenous doxofylline on the basis of the control group, and each group was treated continuously for 2 weeks. The asthma control test (ACT) score, lung function, eosinophils (EOS) count and immunoglobulin E (IgE) levels were assessed or measured before and after treatment, and the main clinical symptom relief time, clinical efficacy and side effects were compared between the two groups. Results The clinical effective rate of the observation group was significantly higher than that of the control group (P<0.05). The main clinical symptoms of asthma, cough, wheezing sound and moist rales were significantly shorter than those of the control group. The significance was statistically significant (P<0.05). Compared with before treatment, the EOS and IgE levels of the two groups were significantly lower after treatment. The significance was statistically significant (P<0.05). The EOS and IgE levels in the observation group were significantly lower than those in the control group. The significance was statistically significant (P<0.05). After treatment, the two groups were treated with forced vital capacity (FVC) and forced expiratory volume1 (FEV1). The peak expiratory flow (PEF) and activated clotting time (ACT) scores were significantly higher. The significance was statistically significant (both P<0.05). The indexes of the observation group were significantly higher than those of the control group with statistically significance (P<0.05). The incidence of adverse reactions in the control group was 11.76％, which was not significantly different from the incidence of adverse reactions in the observation group (16.18％). The significance was statistically significant (P>0.05). Conclusion Inhalation of salbutamol, budesonide combined with doxofylline for the treatment of acute attack of bronchial asthma can quickly restore the main physiological indicators, improve the clinical symptoms of patients and the clinical treatment effects.关键词
多索茶碱/雾化吸入/沙丁胺醇/布地奈德/支气管哮喘/急性发作期Key words
Doxofylline/Aerosol inhalation/Salbutamol/Budesonide/Bronchial asthma/Acute attac分类
医药卫生引用本文复制引用
白明洁,蔺娜..多索茶碱联合雾化吸入药物治疗支气管哮喘急性发作期患者的临床疗效[J].中国药物经济学,2019,14(1):94-97,128,5.
