中国药物经济学2019，Vol.14Issue(2)：87-90,4.DOI:10.12010/j.issn.1673-5846.2019.02.020
奥沙利铂与卡培他滨化疗联合阿瓦斯汀靶向治疗转移性结肠癌的临床疗效
Therapeutic Effects of Targeted Therapy of Oxaliplatin and Capecitabine Combined with Avastin for Metastatic Colon Cancer
张倩馨 1孔妍1
作者信息
- 1. 大连市第三人民医院, 辽宁大连 116033
- 折叠
摘要
Abstract
Objective To investigate the clinical effects of oxaliplatin and capecitabine (XELOX) combined with Avastin in the targeted treatment of metastatic colon cancer. Methods Fifty cases of metastatic colon cancer in The Third People's Hospital in Dalian from May 2013 to July 2016 were selected as the object of study, who were divided into groups by a random number table with 25 cases in each. The control group was given XELOX chemotherapy regimen, while the experimental group was given XELOX chemotherapy regimen combined with Avastin targeted therapy. The short-term and long-term effects and the incidences of toxic and adverse reactions of the 2 groups were counted. Results The disease control rate of the experimental group was 76.00％ (19/25), higher than 44.00％ (11/25) of the control group (P ＜0.05). The progression-free life cycle and total life cycle of the experimental group were longer than those of the control group (P＜0.05). There were no significant differences in the incidences of neurotoxicity, gastrointestinal reaction, bone marrow suppression and leukopenia decrease rate between the experimental group and the control group (P＞0.05). Conclusion The combination of XELOX chemotherapy regimen and Avastin targeted therapy for metastatic colon cancer patients can significantly improve disease control rate as well as prolong progression-free life cycle and total life cycle of patients, with high safety.关键词
转移性结肠癌/阿瓦斯汀/奥沙利铂/卡培他滨/靶向治疗Key words
Metastatic colon cancer/Avastin/Oxaliplatin/Capecitabine/Targeted therapy分类
医药卫生引用本文复制引用
张倩馨,孔妍..奥沙利铂与卡培他滨化疗联合阿瓦斯汀靶向治疗转移性结肠癌的临床疗效[J].中国药物经济学,2019,14(2):87-90,4.
