中国药物评价2018，Vol.35Issue(6)：418-422,5.
头孢丙烯干混悬剂溶出度方法学验证
Dissolution Methodology Validation of Cefprozil for Suspension
柳世萍 1刘海席 2杜金松 2王东凯 2马亚微 1孙婷2
作者信息
- 1. 沈阳药科大学,辽宁 沈阳 110016
- 2. 华北制药河北华民药业有限责任公司,河北 石家庄 052165
- 折叠
摘要
Abstract
Objective:To establish a method for the determination of the dissolution of Cefprozil for Suspension.Methods:Cefprozil content was detected by HPLC and on Kromasil C18column with mobile phase of ammonium dihydrogen phosphate solution (Take 20.7 g of ammonium dihydrogen phosphate, add 1 800 m L of water to dissolve, adjust the p H to 4.4 with phosphoric acid) -Acetonitrile (90:10) and detected at 280 nm, column temperature of 25℃.The dissolution of Cefprozil for Suspension was measured by slurry method 25RPM in water.Results:The dissolution of Cefprozil for Suspension was good on specificity, linearity, precision and recovery etc.Conclusion:The method can accurately determine the dissolution of Cefprozil for Suspension.关键词
头孢丙烯干混悬剂/溶出度/桨法Key words
Cefprozil for Suspension/Dissolution/Slurry method分类
医药卫生引用本文复制引用
柳世萍,刘海席,杜金松,王东凯,马亚微,孙婷..头孢丙烯干混悬剂溶出度方法学验证[J].中国药物评价,2018,35(6):418-422,5.
