中国药物评价2018，Vol.35Issue(6)：435-440,6.
尿激酶、阿替普酶与瑞替普酶对家兔深静脉血栓的影响
Thrombolytic Effects of Urokinase, Alteplase and Reteplase on Inferior Vena Cava Thrombosis in Rabbits
摘要
Abstract
Objective:To observe the thrombolytic effects and hemorrhage of urokinase (UK), alteplase (rt-PA) and reteplase (rPA) on deep venous thrombosis (DVT) in rabbits.Methods:Rabbit models of deep vein thrombosis were prepared by electrical stimulation and stenosis, and uk, rt-PA and r-PA were administered intravenously.The changes of thrombus weight and bleeding after administration were observed.Activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (FIB) were determined using plasma coagulation method, and plasminogen (PLG) levels were measured using chromogenic substrate method.Results:The three thrombolytic agents had significant thrombolytic effects on the thrombus of inferior vena cava in rabbits, and the ability of thrombolytic were r-PA>rt-PA>UK.The three thrombolytic agents caused different degrees of bleeding, and the degrees of bleeding were r-PA>rt-PA>UK.Alteplase significantly prolonged TT, reteplase significantly prolonged PT and TT.r-PA and rt-PA significantly reduced the content of FIB in the plasma, and UK and r-PA significantly reduced the content of PLG in the plasma.Conclusion:The three thrombolytic agents had inhibitory effects on deep venous thrombosis, but bleeding also increased significantly with the increase of efficacy.When thrombolytic agents were used for deep vein thrombolysis treatment, bleeding should be pay close attention.关键词
尿激酶/阿替普酶/瑞替普酶/家兔/深静脉血栓Key words
Urokinase/Alteplase/Reteplase/Rabbit/Deep vein thrombosis分类
医药卫生引用本文复制引用
程建昕,张蕊,郝春华,邱小妙,石冰卓,孙双勇..尿激酶、阿替普酶与瑞替普酶对家兔深静脉血栓的影响[J].中国药物评价,2018,35(6):435-440,6.基金项目
天津市第二批特支计划青年拔尖人才基金(项目编号:TJTZJH-QNBJRC-2-7) （项目编号:TJTZJH-QNBJRC-2-7）
