金锐 1朱建峰 2高之涵 2沈莹 3孙峰俐 3陈正昕 3任志斌 3金卫东2
作者信息
- 1. 浙江省立同德医院药学部,浙江 杭州 310012
- 2. 浙江中医药大学,浙江 杭州 310055
- 3. 浙江省精神卫生中心,浙江 杭州 310012
- 折叠
摘要
Abstract
Objective:To analyze the effects of Oxcarbazepine adjunctive treatment of schizophrenia with excitement.Methods:The effective rate and symptom change were assessed between two groups (Oxcarbazepine vs without Oxcarbazepine) in 5 studies from searching Chinese medical database.Results:1.The scale of excitement symptoms:The excitement of PANSS (positive and negative symptoms scale) was lower significantly in Oxacarbazepine than that of without Oxcarbazepine (test for heterogeneity:χ2=49.02, df=6, P=0.001, I2=87.8％, random effect model:WMD=-3.37, 95％CI=-3.94～-2.81, Z=11.67, P<0.001). The excitement of Moas (Modified Overt Aggression Scale) was lower significantly in Oxacarbazepine than that of without Oxcarbazepine (test for heterogeneity:χ2=60.76, df=4, P=0.001, I2=93.4％, random effect model:WMD=-2.16, 95％CI=-2.49～-1.83, Z=12.84, P<0.001). The excitement of BPRS (brief psychotic rating scale) was lower significantly in Oxacarbazepine than that of without Oxcarbazepine (test for heterogeneity:χ2=2.86, df=7, P=0.90, I2=0％, fixed effect model:WMD=-6.04, 95％CI=-7.56～-4.52, Z=7.80, P<0.001). 2.The higher effective rate was found in Oxacarbazepine group than that without Oxcarbazepine group (test for heterogeneity:χ2=2.45, df=3, P=0.48, I2=0％, fixed effect model:OR=1.65, 95％CI=1.07～2.49, Z=2.39, P=0.02). 3.The recovery rate has not improved between two group (test for heterogeneity:χ2=0.66, df=2, P=0.66, I2=0％, fixed effect model:OR=1.07, 95％CI=0.50～2.29, Z=0.18, P=0.86). Conclusion:The Oxcarbazepine was better in adjunctive treatment in schizophrenic patients with excitement symptom.关键词
奥卡西平/精神分裂症/兴奋状态/Meta分析Key words
Oxcarbazepine/Schizophrenia/Excitement/Meta-analysis分类
医药卫生
