中国医学创新2019，Vol.16Issue(1)：36-39,4.DOI:10.3969/j.issn.1674-4985.2019.01.009
肺表面活性制剂治疗新生儿呼吸窘迫综合征的效果和安全性分析
Effect and Safety of Pulmonary Surfactant in the Treatment of Neonatal Respiratory Distress Syndrome
摘要
Abstract
Objective:To further analyze the effect and safety of pulmonary surfactant in the treatment of neonatal respiratory distress syndrome.Method:A total of 82 cases of neonatal respiratory distress syndrome admitted in our hospital from July 2015 to September 2017 were selected as the research objects.According to the admission time, they were randomly divided into observation group and control group, 41 cases in each group.The control group was given routine treatment, the observation group was given intratracheal administration of pulmonary surfactant on the basis of the control group.The clinical efficacy, oxygen therapy, hospitalization, mechanical ventilation time, hospitalization expenses and complications between the two groups were observed and compared.Result:After treatment, the total effective rate of the observation group was 92.68％, which was significantly higher than 73.17％of the control group, the difference was statistically significant (字2=5.513, P=0.019).The time of oxygen therapy, hospitalization, mechanical ventilation and hospitalization expenses in the observation group were significantly less than those in the control group, the differences were statistically significant (P<0.05).There were 2 cases of pulmonary infection, 3 cases of pulmonary gas leakage and 2 cases of pulmonary hemorrhage in the observation group, 10 cases of pulmonary infection, 13 cases of pulmonary gas leakage and 11cases of pulmonary hemorrhage in the control group.The total incidence of complications in the observation group was 17.07％, which was significantly lower than 82.93％in the control group, the difference was statistically significant (字2=35.561, P<0.001).Conclusion:Pulmonary surfactant in the treatment of neonatal respiratory distress syndrome can effectively reduce complications, has a good curative effect and safety is greatly improved.关键词
肺表面活性制剂/新生儿呼吸窘迫综合征/安全性Key words
Pulmonary surfactant/Neonatal respiratory distress syndrome/Safety引用本文复制引用
崔锐华..肺表面活性制剂治疗新生儿呼吸窘迫综合征的效果和安全性分析[J].中国医学创新,2019,16(1):36-39,4.基金项目
湖北省卫生厅科研基金项目(JX2C42) （JX2C42）
