中国医学创新2019，Vol.16Issue(1)：49-52,4.DOI:10.3969/j.issn.1674-4985.2019.01.012
早期使用重组人干扰素-α1b雾化治疗手足口病的临床效果及对炎症反应的调控作用研究
Study on the Clinical Effect of Early Application of Recombinant Human Interferon-α1b by Atomization Therapy in the Patients with Hand-foot-and-mouth Disease and Regulation Role for Inflammatory Response
摘要
Abstract
Objective:To analyze the clinical effect of early application of Recombinant Human Interferon-α1b by atomization therapy in the patients with hand-foot-and-mouth disease and regulation role for inflammatory response.Method:A total of 92 children with hand-foot-and-mouth disease in our hospital from June 2017 to May2018 were selected.According to the random number table method, they were divided into control group (routine treatment of hand-foot-and-mouth disease) and observation group (routine treatment combined with Recombinant Human Interferon-α1b by atomization therapy), 46 cases in each group.The clinical efficacy, symptoms and signs (fever, oral ulcer and hand-foot rash) improvement time and serum inflammatory cytokine levels (IL-1β, IL-6, IL-10) before and after treatment between two groups were compared.Result:After treatment 3 and 7 days, the clinical total effective rates of observation group were 86.96％and 100％respectively, which were higher than69.57％and 89.13％of control group, the differences were statistically significant (P<0.05).The improvement time of fever, oral ulcer and hand-foot rash in observation group were shorter than those of control group, the differences were statistically significant (P<0.05).After treatment, the levels of IL-1β, IL-6 and IL-10 in observation group were lower than those of control group, the differences were statistically significant (P<0.05).Conclusion:The clinical effect of early application of Recombinant Human Interferon-α1b by atomization therapy in the patients with hand-foot-and-mouth disease is better, and its regulation role for inflammatory response is obvious too, so it is suitable to the clinical treatment of hand-foot-and-mouth disease.关键词
重组人干扰素-α1b/雾化治疗/手足口病/临床效果/炎症反应Key words
Recombinant Human Interferon-α1b/Atomization therapy/Hand-foot-and-mouth disease/Clinical effect/Inflammatory response引用本文复制引用
覃立刚,李宇生,黄慧珠,刘才华..早期使用重组人干扰素-α1b雾化治疗手足口病的临床效果及对炎症反应的调控作用研究[J].中国医学创新,2019,16(1):49-52,4.基金项目
惠州市科技计划项目(20170403) （20170403）
