摘要
Abstract
Objective:To investigate the sedative effect of Dexmedetomidine combined with Sufentanil in patients with multiple injuries.Method:A total of 100 patients with multiple injuries admitted in the ICU of our hospital from April 2015 to April 2018 were selected as the research objects.According to the random number method, they were divided into experimental group and control group, 50 cases in each group.The control group was sedated and analgesic with Sufentanil continuous micro-pump, the experimental group was given Dexmedetomidine combined with Sufentanil continuous micro-pump intravenous infusion.The Ramsay sedation score, time to reach the target and pain visual analogue (VAS) score, hemodynamics and respiratory function indexes before and after treatment and adverse reactions between the two groups were observed and compared.Result:After administration 2, 6, 12, 24, 48 h, the Ramsay sedation scores of the experimental group were significantly better than those of the control group, the time to reach the target was (35.25±0.25) h, which was significantly shorter than (39.60±0.60) h of the control group, the differences were statistically significant (P＜0.05).There were no significant differences in the levels of MAP, SpO2 and HR before and after administration 6, 12, 24 and 48 h between the two groups (P＞0.05).The incidence of nausea, vomiting, sleepiness and respiratory depression in the control group was significantly higher than that in the experimental group, the difference was statistically significant (x2=13.652 4, P＜0.05).After administration 2, 6, 12 and 24 h, the VAS scores of the experimental group were significantly lower than those of the control group, the differences were statistically significant (P＜0.05).Conclusion:Dexmedetomidine combined with Sufentanil has a good sedative effect on patients with multiple injuries and the incidence of adverse symptoms is low, which is worthy of clinical application.关键词
右美托咪定/舒芬太尼/多发伤/镇静效果/Ramsay评分Key words
Dexmedetomidine/Sufentanil/Multiple injuries/Sedative effect/Ramsay score
