中国医学创新2019，Vol.16Issue(2)：37-41,5.DOI:10.3969/j.issn.1674-4985.2019.02.010
维生素C对痛风性关节炎首次发作后预防再发的疗效研究
Effect of Vitamin C on Recurrence of Gouty Arthritis after First Attack
摘要
Abstract
Objective:To investigate the effect of Vitamin C on preventing recurrence of gouty arthritis after the first attack.Method:40 gouty arthritis patients who came to our hospital from January 2017 to September 2017 were selected, patients were divided into control group and observation group according to the random number table method, 20 cases in each group.The observation group was given Vitamin C (500 mg/d) orally, and the control group was not given any drug intervention, follow up for 1 year.Blood uric acid (BUA), triglyceride (TG), total cholesterol (TC), creatinine (Scr) and 24-hour urine uric acid (UUA), uric acid concentration and urine pH value were examined before the treatmentat and 3, 6, 9, 12 months after treatment, the recurrence of gouty arthritis in two groups were recorded.The effects of Vitamin C on serum uric acid and 24-hour uric acid levels in patients with gouty arthritis were analyzed.Result:Comparison of serum BUA, TG, Scr content between the two groups at different time points showed statistically significant differences (P＜0.05) ;compared with before treatment, the serum BUA, TG, Scr content in the control group decreased at 6, 9 and 12 months after treatment, while those in the observation group decreased at 3, 6, 9 and 12 months after treatment;at the 6, 9 and 12 months after treatment, the serum BUA, TG, Scr content of the observation group were lower than those of the control group at the same period, the differences were statistically significant (P＜0.05).There were no statistically significant differences in TC between the two groups at different time points (P＞0.05).The pH value of urine urinuria 24 h at different time points in the two groups were compared, the differences were statistically significant (P＜0.05).Compared with before treatment, the urine pH and 24 h urine uric acid in the control group increased after treatment 6, 9 and 12 months, while those in the observation group increased after treatment 3, 6, 9 and 12 months;the urine pH value and 24 h uric acid urine in the observation group after treatment 6, 9 and 12 months were higher than those in the control group at the same period, the differences were statistically significant (P＜0.05).The patients were observed to have no death or loss of follow-up after treatment, and no adverse reactions were observed.The recurrence rate of the control group was 35.00％, higher than 5.00％ of the observation group, the difference was statistically significant (P＜0.05).The VAS score of the relapse patients in the control group was (4.15±0.77), higher than (2.89±0.31) of the relapse patients in the observation group, the difference was statistically significant (P＜0.05).Conclusion:Vitamin C has a significant preventive effect on the recurrence of gout arthritis after the first attack, it can reduce the content of serum uric acid, increase the excretion of uric acid, relieve the degree of pain, and has high safety, which is worthy of clinical promotion.关键词
维生素C/痛风性关节炎/首次发作/预防再发Key words
Vitamin C/Gouty arthritis/First attack/Prevention of recurrence引用本文复制引用
陈虹燕,周上策,陈卫琴,龙嘉雯..维生素C对痛风性关节炎首次发作后预防再发的疗效研究[J].中国医学创新,2019,16(2):37-41,5.基金项目
2017年番禺区科技计划项目(2017-Z04-51) （2017-Z04-51）
