中国医学创新2019，Vol.16Issue(3)：1-5,5.DOI:10.3969/j.issn.1674-4985.2019.03.001
NK1受体基因多态性与腹腔镜手术PONV的相关性分析
Relationship of Common Genomic Variations of NK1 Receptor Gene and the Incidence of Postoperative Vomiting in Patients Underwent Laparoscopic Surgery
摘要
Abstract
Objective:To explore the relationship of common genomic variations of NK1 receptor gene and the incidence of postoperative vomiting in patients underwent laparoscopic surgery.Method:We conducted a prospective observational study design of 80 patients who underwent elective laparoscopic surgery, aged 18 to 65 years old. 5 mL peripheral blood before surgery was collected, genomic DNA extraction kit was used to extract DNA, allele-specific amplification was used to genotype NK1 receptor gene, and DNA sequencing was used to genotype single nucleotide polymorphism of NK1 receptor.The rates and time and score of nausea and vomiting were measured, and the VAS, the dosage of analgesic and antemetic were measured as well.Vomiting and retching were considered vomiting events in this study, we also recorded the circulation perioperative and the adverse reaction.Result:According to the variable sit of single nucleotide polymorphisms, we found three types, 21 cases of homozygous wild type (wt/wt group, 26.3％), 25 cases of mutant heterozygote (wt/mut group, 31.3％), 34 cases of homozygous mutant (mut/mut group, 42.5％).There were 6 patients had PONV in homozygous mutant group, the total incidence was 17.6％ which was lower than the others (P＜0.05).Conclusion:The genomic variations of the NK1 receptor gene has a relationship of postoperative vomiting and nausea in patients who underwent gynecological laparoscopic surgery, and the incidence of PONV in homozygous mutant is lower than those of the others.关键词
NK1受体/PONV/单核苷酸基因多态性Key words
NK1 receptor/PONV/Single nucleotide polymorphisms引用本文复制引用
邹聪华,郑晓春,陈烨..NK1受体基因多态性与腹腔镜手术PONV的相关性分析[J].中国医学创新,2019,16(3):1-5,5.基金项目
福建省卫生厅青年科研课题(2015050) （2015050）
