中国医学创新2019，Vol.16Issue(3)：16-20,5.DOI:10.3969/j.issn.1674-4985.2019.03.004
胰岛素皮下持续输注对初诊2型糖尿病患者胰岛功能及炎症因子的影响
Effects of Continuous Subcutaneous Insulin Infusion on Pancreatic Islet Function and Inflammatory Factors in Newly Diagnosed Type 2 Diabetes Mellitus
摘要
Abstract
Objective:To observe the effect of continuous subcutaneous insulin infusion (CSⅡ) on pancreatic islet function and inflammatory factors in newly diagnosed type 2 diabetes mellitus (T2DM). Method:A total of 72 newly diagnosed patients with T2DM in our hospital from January 2017 to June 2018 were selected.According to the order of admission, they were divided into CSⅡ group and MSII group, 36 cases in each group.CSⅡ group was treated with CSⅡ, and MSII group was treated with MSII, they were treated for 2 weeks.The blood glucose (FPG, 2 h PG and HbA1c), pancreatic islet β function (FINS, HOMA-β, HOMAIR), inflammatory response index (CRP, IL-6 and TNF-α) before and after treatment, and insulin dosage, time of blood sugar reaching the standard and frequency of hypoglycemia between two groups were compared. Result:After treatment, the levels of FPG, 2 h PG, HbA1 c, HOMA-IR, CRP, IL-6 and TNF-α in CSⅡ group were lower than those of before treatment and MSII group, the differences were statistically significant (P＜0.05).The levels of FINS and HOMA-β in CSⅡ group were higher than those of before treatment and MSII group, the differences were statistically significant (P＜0.05).The insulin dosage, time of blood sugar reaching the standard and frequency of hypoglycemia in CSⅡ group were less than those of MSII group, the differences were statistically significant (P＜0.05).Conclusion:CSⅡ can effectively improve the pancreatic islet β function and inflammatory response of newly diagnosed T2DM patients.It is beneficial to control the level of blood sugar and delay the progression of the disease.Therefore, it can be used as the main treatment method for the newly diagnosis of T2DM.关键词
初诊2型糖尿病/胰岛素皮下持续输注/血糖/胰岛功能/炎症因子Key words
Newly diagnosed type 2 diabetes mellitus/Continuous subcutaneous insulin infusion/Blood glucose/Pancreatic islet function/Inflammatory factors引用本文复制引用
蔡茵瑜,史伟文..胰岛素皮下持续输注对初诊2型糖尿病患者胰岛功能及炎症因子的影响[J].中国医学创新,2019,16(3):16-20,5.基金项目
广东省医学科学技术研究基金项目(A2016457) （A2016457）
