中国医学创新2019，Vol.16Issue(3)：25-29,5.DOI:10.3969/j.issn.1674-4985.2019.03.006
抑郁症患者静息态功能磁共振与睡眠结构研究
Resting-state Functional Magnetic Resonance Imaging and Sleep Structure Analyze in Depression
摘要
Abstract
Objective:To study the characteristics of sleep structure and resting brain activity in patients with depression.Method:A total of 19 patients with first-episode unipolar depression were selected as case group and 10 healthy persons as control group.Resting-state functional magnetic resonance imaging (rfMRI) and sleep electroencephalogram were performed in both groups, and ReHo and ALFF were used for magnetic resonance analysis.The results of two groups were compared.Result:The sleep latency of case group was longer than that of control group, sleep efficiency, the proportion of N3 and REM stages were lower than those of control group, and the proportion of stage N1 and N2 was higher than that of control group, the differences were statistically significant (P＜0.05).Compared with the control group, the ReHo values of left fusiform gyrus and left posterior cerebellar lobe decreased, the ReHo values of right superior parietal lobe, left precuneus and right occipital lobe lingual gyrus increased, the ALFF values of right frontal lobe straight gyrus, right occipital lobe lingual gyrus, left posterior cerebellar lobe and right anterior cerebellar lobe decreased, and the ALFF values of right cuneus increased, the differences were statistically significant (P＜0.05).Conclusion:Patients with first-episode unipolar depression with sleep disorders have multiple regional brain dysfunction.关键词
抑郁/睡眠/静息态功能磁共振/睡眠脑电图Key words
Depression/Sleep/Resting-state functional magnetic resonance imaging/Polysomnography引用本文复制引用
赖明君,潘小平,魏新华,郑浩,任继亮,徐向东,周进..抑郁症患者静息态功能磁共振与睡眠结构研究[J].中国医学创新,2019,16(3):25-29,5.基金项目
广州市医药卫生科技一般引导项目(20161A010013) （20161A010013）
广州市产学研协同创新重大专项(2016201604030018) （2016201604030018）
