中国医学创新2019，Vol.16Issue(3)：45-48,4.DOI:10.3969/j.issn.1674-4985.2019.03.011
婴幼儿血清25-羟维生素D与骨密度的相关性分析
Correlation Analysis between Serum 25-hydroxyvitamin D and Bone Mineral Density in Infants and Young Children
摘要
Abstract
Objective:To discuss the correlation between serum 25-hydroxyvitamin D [25- (OH) D]and bone mineral density (BMD) in infants and young children.Method:A total of 354 infants and young children with clinical symptoms of short stature, malnutrition, night terror, profuse sweating and agitation treated in Children's Rehabilitation Department of our hospital from June 2015 to June 2016 were selected as the study objects.Serum 25- (OH) D and bone mineral density of infants and young children were measured.The 25- (OH) D and bone mineral density in infants and young children at different age groups were compared and correlation of 25- (OH) D and bone mineral density was analyzed.Result:The average levels of 25- (OH) D and bone mineral density of 354 infants and young children were (28.32±9.15) ng/mL and (-1.33±0.49) respectively.With the increase of month age, the levels of 25- (OH) D and bone mineral density decreased gradually, and there were significant differences among different age groups (P＜0.05).There were no significant differences in 25- (OH) D and bone mineral density levels of different age groups between male and female infants (P＞0.05).There were significant differences in the ratio of 25- (OH) D among different age groups (X2 =51.653, P＜0.001).The higher the age, the higher the rate of serious insufficiency.There were significant differences in the ratio of bone mineral density among different age groups (X2=33.964, P＜0.001).The higher the age, the higher the rate of severe insufficiency.The proportion of 25- (OH) D deficiency in the total level of slight, moderate and severe bone mineral density deficiency were significantly higher than those in the normal proportion, the differences were statistically significant (P＜0.05).There was a positive correlation between 25- (OH) D level and Z value of bone mineral density in infants and young children (r=0.819, P＜0.001).Conclusion:25- (OH) D has a certain correlation with bone mineral density, which can guide the supplementation of vitamin D and calcium according to the levels of 25- (OH) D and bone mineral density.The early intervention of vitamin D deficiency is of great significance to the skeletal development of infants and children and the prevention of rickets.It is worthy of further clinical study.关键词
血清25-羟维生素D/骨密度/相关性分析Key words
Serum 25-hydroxyvitamin D/Bone mineral density/Correlation analysis引用本文复制引用
林小芹,魏明香..婴幼儿血清25-羟维生素D与骨密度的相关性分析[J].中国医学创新,2019,16(3):45-48,4.基金项目
韶关市科技计划项目(2013CX/K102) （2013CX/K102）
