中国医学创新2019，Vol.16Issue(3)：49-52,4.DOI:10.3969/j.issn.1674-4985.2019.03.012
右美托咪定联合丙泊酚对老年患者全身麻醉苏醒期躁动及血浆皮质醇水平的影响
Effect of Dexmedetomidine Combined with Propofol on Agitation and Plasma Cortisol Levels during General Anesthesia Recovery in Elderly Patients
摘要
Abstract
Objective:To discuss the effect of Dexmedetomidine combined with Propofol on agitation and plasma cortisol levels during general anesthesia recovery in elderly patients.Method:A total of 60 elderly patients who underwent selective surgeries of orthopedic surgery under general anesthesia in our hospital from January 2016 to October 2017 were selected as the study objects.According to the random number table method, they were divided into Propofol group (group P) and Dexmedetomidine group combined with Propofol group (group DP), 30 cases in each group.DP group was given 0.5 μg/kg (15 min) of Dexmedetomidine intravenously before induction of anesthesia, and 0.2 μg/ (kg·h) was continuously infused during operation until 5 min before the end of operation.Both groups were given Atracurium 0.7 mg/kg, Propofol 1-3 mg/kg and Sufentanil targetcontrolled concentration 0.2 μg/kg to induce intubation.BIS value was maintained at 45-55 by adjusting Propofol target-controlled plasma concentration during operation.The plasma cortisol concentration at each time point, Riker sedation-agitation scale (RSAS) score and agitation during general anesthesia recovery between the two groups were observed and compared.Result:The RSAS score and incidence of agitation during general anesthesia recovery in group DP were significantly lower than those in group P, the differences were statistically significant (P＜0.05).The plasma cortisol concentration at T0, T1, T2 and T3 time points of group DP were significantly lower than those of group P, the differences were statistically significant (P＜0.05).Conclusion:The application of Dexmedetomidine under the plasma target-controlled infusion anesthesia with Propofol can inhibit and prevent the irritable response and agitation of the elderly patients undergoing orthopaedic surgery under general anesthesia respectively.关键词
右美托咪定/丙泊酚/老年学/躁动/皮质醇Key words
Dexmedetomidine/Propofol/Gerontology/Agitation/Cortisol引用本文复制引用
林丽田,彭惠华..右美托咪定联合丙泊酚对老年患者全身麻醉苏醒期躁动及血浆皮质醇水平的影响[J].中国医学创新,2019,16(3):49-52,4.基金项目
广东省科技计划项目(2017B020247035) （2017B020247035）
