中国药业2018，Vol.27Issue(21)：12-14,3.DOI:10.3969/j.issn.1006-4931.2018.21.004
匹多莫德水溶液稳定性研究
Study on Stability of Pidotimod Aqueous Solution
于士龙 1罗胜男 2徐菁阳 1崔思娇 1汪宇1
作者信息
- 1. 中国人民解放军第463医院, 辽宁 沈阳 110042
- 2. 沈阳药科大学, 辽宁 沈阳 110000
- 折叠
摘要
Abstract
Objective To investigate the stability of pidotimod aqueous solution under different conditions, and to provide a basis for the formulation of quality standards of related preparations. Method Pidotimod aqueous samples with different p H were made up, and the content of pidotimod samples were determined by HPLC under three conditions: room temperature and normal light, 60 ℃ and normal light, room temperature and hard light (4 500 lx), and its stability was inspected. Results Under the three kinds of conditions, the content of pidotimod aqueous solution had the same change trend, its most stable pH range was 6-8. According to content change degree, the stability of room temperature and normal light was the best and the stability of 60 ℃ and normal light was the worst. Conclusion Pidotimod queous solution can maintain the best stability at room temperature without light and its pH should be adjusted to 6-8.关键词
匹多莫德/高效液相色谱法/稳定性/pH/光照试验Key words
pidotimod/HPLC/stability/pH/illumination test分类
医药卫生引用本文复制引用
于士龙,罗胜男,徐菁阳,崔思娇,汪宇..匹多莫德水溶液稳定性研究[J].中国药业,2018,27(21):12-14,3.
