中国药业2018，Vol.27Issue(21)：46-48,3.DOI:10.3969/j.issn.1006-4931.2018.21.014
不同时间点静脉滴注氨甲环酸对全髋关节置换术围术期出血及术后静脉血栓栓塞发生率的影响
Effects of Intravenous Drip of Tranexamic Acid at Different Time Points on Incidence Rates of Perioperative Hemorrhage and Postoperative Venous Thromboembolism in Patients Undergoing Total Hip Arthroplasty
摘要
Abstract
Objective To investigate the effects of intravenous drip in tranexamic acid at different time points on the incidence rates of perioperative hemorrhage and postoperative venous thromboembolism (VTE) in patients undergoing total hip arthroplasty (THA). Methods Totally 126 patients treated with THA were selected and divided into the observation group, control group 1 and control group 2 according to the random number table method, 42 cases in each group. The control group 1 was given intravenous drip of tranexamic acid at 30 min before incision, the control group 2 was given intravenous drip of tranexamic acid at 30 min before incision closure, and the observation group was given intravenous drip of tranexamic acid at the two time points. Results 1 d after operation, the levels of D-dimer (D-D), fibrin degradation products (FDP), C-reactive protein (CRP) and interleukin-6 (IL-6) in the three groups were significantly higher than those before operation, and those in the observation group were significantly lower than those in the two control groups (P ＜ 0. 05). There was no significant difference in operative time among the 3 groups (P＞ 0. 05), while the intraoperative blood loss, blood loss within 3 d after operation, drainage volume within 3 d after operation, the maximum difference of hemoglobin decline within 3 d after operation, and the cases of blood transfusion within 3 d after operation in the observation group were significantly less than those in two control groups (P ＜ 0. 05). Within 1 week after operation, there was no statistical significance in the incidence rates of VTE, pulmonary infection and incision infection among the three groups (P＞ 0. 05). Conclusion Intravenous drip of tranexamic acid before incision and before incision closure in patients undergoing THA can effectively reduce perioperative hemorrhage, and it will not increase the incidence rate of postoperative VTE, it is favorable for the prognosis and recovery of patients.关键词
氨甲环酸/出血/静脉血栓栓塞/全髋关节置换术Key words
tranexamic acid/hemorrhage/venous thromboembolism/total hip arthroplasty分类
医药卫生引用本文复制引用
杜燕,赵泽宇,唐涛,苟远涛..不同时间点静脉滴注氨甲环酸对全髋关节置换术围术期出血及术后静脉血栓栓塞发生率的影响[J].中国药业,2018,27(21):46-48,3.基金项目
四川省卫生和计划生育委员会科研课题[16ZD042] （）
